lipoglycopeptide

Question 1

what are these drugs?

Answer 1

vancomycin analogues

Question 2

what are the agents

Answer 2

dalbavancin, telavacin, oritavancin

Question 3

what is unique about these

Answer 3

they have a lipophilic side chain that increases binding

Question 4

what general mechanism to there all share?

Answer 4

they all inhibit the transglycosylation by binding to the d-ala-d-ala, just like vancomycin

Question 5

what additional mechanisms does oritavancin have

Answer 5

interacts and disrupts the cell membrane. binds the pentagly bridging segment and inhibits the transpeptidation

Question 6

what additional mechanism does telavancin have

Answer 6

interaction and disruption of the cell membrane.

Question 7

what isi the spectrum of dalbavancin

Answer 7

(+): MRSA, MSSA, strep, coagulase (-) staph. anaerobes: clostridium species, p acnes, peptostreptococcus.

Question 8

what is the spectrum for oritavancin

Answer 8

same as dalbavancin but active against VRE.

Question 9

what is the spectrum for telavancin

Answer 9

same but also active against VRE.

Question 10

what are the relative half lives of these drugs

Answer 10

telavancin has the least do to renal excretion. dalbavancin has the highest at 257hrs.

Question 11

what is the clinical use of these drugs?

Answer 11

skin and soft tissue infections.

Question 12

what are the SE/

Answer 12

metallic taste, nausea, HA, nephrotoxic. teratogenic.