tetracyclines

Question 1

what is the major subclass

Answer 1

protein synthesis inhibitors

Question 2

what is the mechanism

Answer 2

passive diffusion through porins in gram (-) organism binds to the 30s ribosomal subunit and inhibits protein synthesis

Question 3

what are the resistances to these

Answer 3

efflux pumps, ribosomal protection through dissociation from binding sites.

Question 4

spectrum

Answer 4

atypical organisms, spirochetes (borrelia), gram (+) (pneurmoniae, CA-MRSA), gram (-) (h flu, neisseria, rickettsia)

Question 5

clinical uses

Answer 5

uncompl. respiratory infections (bronchitis, sinusitis, CAP), tick born illnesses, h. pylori.

Question 6

adverse effects

Answer 6

GI, photosensivity, discoloration of the teeth of children (dose related), pill esophagitis (take with water and stand up),

Question 7

what are the interactionsq

Answer 7

chelate cations in multivitamins, ca, iron, antacids. separate by a few hours.

Question 8

what are the agents?

Answer 8

doxycycline, minocycline, tetracycline