aminoglycosides

Question 1

what is the class of these drugs

Answer 1

protein synthesis inhibitors that work on the 30s ribosomal subunit

Question 2

what drugs are in this subclass

Answer 2

gentamycin, amikacin, tobramycin, streptomycin.

Question 3

mechanism of action

Answer 3

oxygen dependent active transport across the membrane binds to 30s subunit and interferes with the initiation complex. inhibits protein synthesis.

Question 4

what is the resistance to these drugs>

Answer 4

reduced uptake or decreased permeability, altered ribosomal binding sites, enzymatic alteration.

Question 5

spectrum

Answer 5

gram (+) active against enterococcus. cannot give as monotherapy. gram (-): enterobactericae, pseudomonas.

Question 6

what do these drugs not work on?

Answer 6

anaerobes.

Question 7

clinical uses

Answer 7

gram (-) sepsis, UTI, sombination with ampicillin, vancomycin for enterococcal. combine with penicillin for viridans endocarditis

Question 8

how are these drugs eliminated

Answer 8

almost exclusively by the urine

Question 9

what are the SE

Answer 9

nephrotoxic. ototoxic (risk increased with loop diuretic). neuromuscular block.