glycyclines Flashcards
1
Q
what is the agent
A
tigecycline
2
Q
what is the mechanism
A
derivative of minocycline that enhances ribosomal permeation and binding. it overcomes the efflux pump and ribosomal protection. lk
3
Q
is this drug bacteriocidal
A
no its bacteriostatic because the interaction with the ribosome is reversible
4
Q
spectrum
A
broad. negative, positive, anaerobes, includes MRSA, VRE, acinetobacter. atypicals.
5
Q
what does this not treat
A
providencia, proteus, pseudomonas.
6
Q
clinical uses
A
complicated skin infections and soft tissue, intra-abdominal, MDR infections (CRE),
7
Q
what are the adverse affects
A
GI nausea/vomiting, diarrhea, increased LFTs,
8
Q
what is this not used for?
A
bacteremia due to its tissue distribution, there is actually a low concentration in the serum.
