Leprosy

Question 1

causative agent of leprosy

Answer 1

Mycobacterium leprae

Question 2

another name for leprosy

Answer 2

Hansen’s disease

Question 3

true or false: Leprosy has no acute illness

Answer 3

true

Question 4

Which is false about M.leprae?
a. Waxy coating
b. able to grow in vitro
c. transmission is by nasal/oral droplets & dermal
inoculations
d. mainly a granulomatous disease

Answer 4

B

lack of genes needed for independent growth; need nude mice and nine-banded armadillos for
animal models

Question 5

Pick which cannot be done for diagnosis of M.leprae
A.serologic test
B.skin biopsy
C.look for clinical signs
D.test for peripheral nerve thickening and tenderness

Answer 5

A

Question 6

identify: primary external sign of Hansen’s disease

Answer 6

skin lesions

Question 7

true or false: Leprosy can cause body parts to fall off

Answer 7

false

however:
Tissues are numb –> microbial invasion –> secondary infection –> weakens the body’s defenses

Question 8

Explain M.leprae’s nerve damage mechanism

Answer 8

entry through blood vessels–>inflammatory response –>demyelination

Question 9

stain used for skin smear test (M.leprae)

Answer 9

Ziehl Neelsen Carbol Fuschin Stain

Question 10

Which is the more severe skin lesion, tuberculoid or lepromatous?

Answer 10

lepromatous

Question 11

Where are many erythematous macules found?
A. tuberculoid
B. lepromatous
C. both A and B

Answer 11

B

Question 12

Where can nerve enlargement be found?
A. tuberculoid
B. lepromatous
C. both A and B

Answer 12

A

Question 13

Where can Langerhans cells be found?
A. tuberculoid
B. lepromatous
C. both A and B

Answer 13

A

Question 14

Where does one experience Hypergammaglobulinemia?
A. tuberculoid
B. lepromatous
C. both A and B

Answer 14

B

Question 15

Where does one experience erythema nosodum?
A. tuberculoid
B. lepromatous
C. both A and B

Answer 15

B

Question 16

Which classification system groups leprosy cases as paucibacillary and bacillary?
A. 2009 WHO Classification System
B. Ridley – Jopling System
C. both of the above
D. none of the above

Answer 16

A

Question 17

Define “paucibacillary”

Answer 17

skin lesions with no bacilli seen in a skin smear

Question 18

__= Key to Progression

Fill in the blank

Answer 18

late treatment

Question 19

Dapsone, a drug used to treat leprosy, inhibits this substance. Identify.

Answer 19

dihydropteroate synthase

Question 20

Dapsone inhibits ___ synthesis

Answer 20

nucleic acid

Question 21

Rifampicin inhibits synthesis of
A. DNA
B. RNA
C. both A and B

Answer 21

B

Question 22

False about Type 1/Borderline leprosy
A. Delayed hypersensitivity occurring at the site of
localized M. leprae antigens
B. Skin lesions appear and are erythematous
C. Peripheral nerves become tender and painful
D. Loss of nerve function is gradual

Answer 22

D

it can be sudden

Question 23

In Type 2/Borderline Lepromatous and Lepromatous cases, What results from
immune complex deposition?

Answer 23

Erythema nodusum leprosum (ENL)

Question 24

All of the ff are final 3 countries that have leprosy, except:
A.Brazil
B.Egypt
C.Nepal
D.Timor-Leste

Answer 24

b