Metabolic Bone Disease

Question 1

• Low mineral density–>loss of bone integrity
• Bone density Scan
• Ca; Vit. D; bisphosphonates

Answer 1

Osteoporosis/penia

Question 2

• Defective skeletal mineralization
• Vit. D deficiency most common cause
• Asymptomatic, bone pain, painful proximal muscle weakness, easy fx’s
• Decreased Ca, Vit. D, phosphate,
• Vitd. D & Ca

Answer 2

Osteomalacia

Question 3

• Boney lesions with high bone turnover and disorganized osteoid formation
• Often asymptomatic, bone pain
• Bone becomes soft–>kyphosis, bowed tibias, frequent fxs
• Dense, expanded bones on X-ray
• Bisphosphonates

Answer 3

Paget Disease

Question 4

• Bone fragility
• Fx’s from minor trauma; hearing loss
• IV Pamidronate

Answer 4

Osteogenesis Imperfecta