Cytokines

Question 1

What does IL-1 do?

Answer 1

Pyrogenic, inflammatory

Question 2

Which IL causes fever? What secretes it?

Answer 2

IL-1 from macrophages

Question 3

Which IL stimulates T cells? What secretes it?

Answer 3

IL-2 from T cells themselves

Question 4

What does IL-2 do?

Answer 4

Stimulates all T cells

Question 5

What does IL-3 do?

Answer 5

Stimulates bone marrow

Question 6

Which IL stimulates growth and differentiation of bone marrow? What secretes it?

Answer 6

IL-3 from T cells, functions like GM-CSF (granulocyte macrophage colony stimulating factor)

Question 7

What does IL-4 do?

Answer 7

Stimulates IgE production (and IgG)

Question 8

Which IL stimulates IgE production? What secretes it?

Answer 8

IL-4 from Th2 cells

Question 9

What does IL-5 do?

Answer 9

IgA, Eosinophils

Question 10

Which IL stimulates IgA production? What secretes it?

Answer 10

IL-5 from Th2 cells

Question 11

What does IL-6 do?

Answer 11

Pyrogenic

Question 12

What does IL-8 do?

Answer 12

Neutrophil chemotaxis

Question 13

What does IL-12 do?

Answer 13

Differentiation into Th1 cells, activate NK cells

Question 14

What does TNF-a do?

Answer 14

Mediates septic shock

Question 15

Which IL is a major neutrophil chemotactic factor?

Answer 15

IL-8

Question 16

Which cytokines are secreted by macrophages?

Answer 16

IL-1, IL-6, IL-8, IL-12, TNF-a

Question 17

Which cytokines are secreted by all T cells?

Answer 17

IL-2, IL-3

Question 18

What does IFN-y do?

Answer 18

Activates macrophages and Th1 cells. Suppresses Th2 cells.

Question 19

What does IL-10 do?

Answer 19

Modulates inflammatory response

Question 20

Which cytokines are secreted by Th2 cells?

Answer 20

IL-4, IL-5, IL-10, IL-13

Question 21

Which cytokine inhibits Th2 cells?

Answer 21

IFN-y from Th1

Question 22

Which cytokine is secreted by Th1 cells?

Answer 22

IFN-y

Question 23

Which cytokines inhibit Th1 cells?

Answer 23

IL-4 and IL-10 from Th2