Menopause Flashcards
The primary driver of ovarian aging is the decline in the number of
follicles
Germ cells arrive at the genital ridge and begin to form at week
6
Ovaries differentiate at weeks, and oocytes (matured from oogonia) begin __ but then __
8-12; meiosis; arrest
Ovarian follicular formation begins at weeks
16-20
During birth the ovaries are __ with both ___ growth and atresia
active; follicular
The rate of follicular atresia becomes more rapid when?
10-15 years prior to menopause
Lower number of follicles results in irregular __ and lower rates of
cycles; pregnancy
Diagnosis of menopause comes after no ___ for a ___
periods; year
Menopause have higher levels of __ and lower levels of __
FSH and LH; estrogen due to loss of estrogen negative feedback on HPA axis
Women have lower rates but higher mortality of both __ and __
CVD; MI
Coronary and bone effects due to menopause are caused by
decrease in estrogen levels
25% of women will have hotflashes for more than _ years, but most average _ years
5; 5
Three major risk factors for menopausal women
smoking, race, obesity
Median age of menopause is between __ and __ years
50; 52
The hallmark treatment of menopausal treatment is
estrogen replacement therapy
