Genetic Breast Cancer Flashcards

1
Q

The single most dietary factor for breast cancer is

A

alcohol

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2
Q

The mutation is the __ gene trumps any minor risk factors for the individual but minor risk factors like ___ are more important at the population level

A

BRCA; obesity

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3
Q

Breast cancers have less __ components and are more sporadic

A

hereditary

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4
Q

BRCA genes code for ____ ___ and need a loss of __ to be deletrious

A

tumor suppressors; heterozygosity

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5
Q

BRCA2 is implicated in causing other cancers with the exception of ___ cancer, which BRCA1 is more associated with

A

ovarian

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6
Q

__ jews should be tested for breast cancer gene

A

Ashkenazi

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7
Q

The ___ procedure reduces the risk of both breast and ovarian cancer

A

salpingo-oophorectomy

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8
Q

BRCA genes repair

A

DS DNA breaks

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9
Q

PARP inhibitors cause __ in cells

A

DS DNA breaks

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10
Q

Patients who have relatives with breast cancer and are ___ __ should undergo the same breast cancer screenings as the population

A

true negatives

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11
Q

CDH1 mutations are associated with __ cancer

A

gastric

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