Breast Path

Question 1

__ changes in the breast is a risk factor for breast cancer

Answer 1

fibrocystic

Question 2

In Situ carcinomas do not ____ and they proliferate where?

Answer 2

spread; in their original location

Question 3

DCIS is a _ __ precursor of ___ ___

Answer 3

non-obligate; invasive carcinomas

Question 4

DCIS show ___ ___ on path

Answer 4

calcified necrosis

Question 5

Clinically, DCIS are __ (feature) and ___ (treatment)

Answer 5

benign; treatable

Question 6

LCIS cells proliferate and destroy the original

Answer 6

lumen

Question 7

LCIS are only seen __ on imaging

Answer 7

incidentally

Question 8

LCIS frequently has __ __ cells on path

Answer 8

signet ring

Question 9

LCIS treatment is ___ and __ (style) or ___ (drug) rather than mastectomy

Answer 9

watch and wait; tamoxifen

Question 10

DCIS can be seen on a __ which is the most common way they’re found

Answer 10

mammogram

Question 11

__ disease of the ___ signifies an underlying breast cancer which has spread from the ducts to the skin of the nipple. Can be __ __ or __. Presents with a __ of the nipple

Answer 11

Paget; nipple; in-situ; invasive; crusting

Question 12

__ breast carcinoma presents with reddening of the breast and is a serious form of cancer. There are no __ cells but cancer is seen in the __ lymphatics

Answer 12

Inflammatory; inflammatory; dermal

Question 13

What does the TMN staging shorthand stand for?

Answer 13

Tumor size, metastasis, lymph nodes

Question 14

Predictive markers look for what two receptors and why?

Answer 14

estrogen and progesterone, to predict response to anti-hormonal treatment

Question 15

___ protein overexpression predicts response to __ (drug)

Answer 15

Her-2; trastuzumab

Question 16

Oncotype DX tests work in patients with what 3 characteristics?

Answer 16

ER-positive, node-negative, and can withstand 5 years of tamoxifen

Question 17

Oncotype DX low risk patients get no __; high risk groups get ___; the middle is unclear

Answer 17

chemo

Question 18

__ syndrome is a risk factor for male breast cancer: so is the __ gene

Answer 18

Klinefelter (xxy); BRCA2

Question 19

Male breast cancer is ___ only

Answer 19

ductal