‼️BIOCHEM-Special Topics

Question 1

Examples of acidic sugars

Answer 1

Glucuronic acid

Iduronic acid

Question 2

GAG in mast cells

Answer 2

Heparin

Question 3

All GAGs are attached to proteins to form

Answer 3

Proteoglycans

Question 4

GAG located at sites of calcification in endochondral bone and are also found in cartilage

Answer 4

Chondroitin sulfate

Question 5

GAGs that play a role in corneal transparency

Answer 5

Keratan sulfate I and dermatan sulfate

Question 6

GAG Structural role in sclera

Answer 6

Dermatan sulfate

Question 7

Heparin binds with factors

Answer 7

IX and XI

Question 8

GAG that determines the charge selectiveness of renal glomerulus

Answer 8

Heparan sulfate

Question 9

Synthesis of GAGs occur in which organelles?

Answer 9

ER and golgi apparatus

Question 10

How are GAGs degraded?

Answer 10

They are phagocytosed and vesicles fuse with lysosomes where they are degraded

Question 11

Lysosomal degradationof GAGs are accomplished by

Answer 11

Acid hydrolases

Question 12

Accumulation of GAGs in lysosomes due to deficiency in hydrolases

Answer 12

Mucopolysaccharidoses

Question 13

All mucopolysaccharidoses are autosomal recessive except for

Answer 13

Hunter’s syndrome (x-linked recessive)

Question 14

All mucopolysaccharidoses have mental retardation except

Answer 14

Morquio’s syndrome

No CNS involvement

Question 15

Mucopolysaccharidoseses with deficiency in alpha L iduronidase

Answer 15

Hurler’s and Scheie’s syndrome

Question 16

Type VII mucopolysaccharidoses

Enzyme deficiency?

Answer 16

Sly syndrome

Beta glucoronidase

Question 17

Type II mucopolysaccharidoses

Enzyme deficient?

Answer 17

Hunter’s syndrome

Iduronate sulfatase

Question 18

Type III mucopolysaccharidoses

Answer 18

Sanfilippo syndrome

Question 19

Morquio’s syndrome is deficient in

Answer 19

Galactose 6 sulfatase

Question 20

Proteins to which oligosaccharides are covalently attached

Answer 20

Glycoproteins

Question 21

Length of carbohydrate chain in gycoprotein is relatively

Vs proteoglycans

Answer 21

Short and branched

Proteoglycans: linear and longer

Question 22

Sugar units in glycoproteins vs proteoglycans

Answer 22

GP - NO repeating sugar units

PG- WITH repeating sugar units

Question 23

Major classes of glycoproteins

Answer 23

O- linked
N-linked
GPI-linked

Question 24

O-linked glycoproteins are bound to which amino acids

Answer 24

Serine and threonine

Question 25

N-linked glycoproteins are bound to what amino acid?

Answer 25

Asparagine

Question 26

Production of O-linked vs N-linked Glycoprotein

Answer 26

O-linked gOlgi apparatus

N-linked eNdoplasmic ret

Question 27

R group

O-linked vs N-linked

Answer 27

o- hydroxyl

n- amide

Question 28

Glycosaminoglycans are generally composed of

Answer 28

Repeating disaccharide units

Amino sugar
Acidic sugar