Gastric Cancer Flashcards
1
Q
What types of cancers are the majority of gastric cancer?
A
Adenocarcinoma (90%)
2
Q
Where is the highest incidence of gastric cancer?
A
-east asia, eastern Europe and south america
3
Q
What are the risk factors for gastric cancer?
A
- consumption of smoked and salted foods
- H. pylori infection
- smoking
- genetics
- PUD doesn’t increase risk
4
Q
What is the pathophysiology of gastric cancer?
A
- loss of p53
- oncogenes, ras, c-myc, HER2
5
Q
What are the classifications of gastric cancer?
A
- according to location in the stomach, gross and histologic morphology
- diffuse morphology: diffuse, infiltrative growth pattern, occurs in younger people, worse prognosis
- intestinal morphology: bulky tumours composed of glandular structures
- other types can by lymphoma
6
Q
What are key diagnostic factors in gastric cancer?
A
- abdominal pain worse with eating and vague
- weight loss
- dysphagia
- nauseas
7
Q
What are investigations for gastric cancer?
A
- gastroscope
- CT
- CXR (metastatic lesions)
- PET
8
Q
How is it staged?
A
TNM system
9
Q
What are DDx for gastric cancer?
A
- PUD
- Benign oesophageal strictures
- Achalasia
10
Q
What is the treatment for gastric cancer?
A
- localised malignancy is surgery and chemo,radiotherapy
- if not localised then chemoradiation
