Receptors

Question 1

what is the “central dogma” of receptor activation?

Answer 1

lock and key

Question 2

what is the lock and key mechanism?

Answer 2

Binding is SPECIFIC, based on the complimentary shape and charge of the ligand and the receptor

Question 3

what are the two basic types of receptors?

Answer 3

1) Generalized or Drug receptor: anything that a drug binds to (enzyme, channel, transporter, cytoskeleton, etc.) is the receptor for that drug…
2) Specialized or biological: proteins that mediate the transfer of information from outside of a cell to inside the cell; they have no other function.

Question 4

what are the 4 superfamilies of receptors?

Answer 4

1. Ligand-gated channels
2. G protein coupled receptors (GPCRs)
3. Enzyme/cytokine receptors
4. Ligand-activated transcription factors

Question 5

what are the 3 basic steps of signal transduction?

Answer 5

1. reception
2. transduction
3. response

Question 6

T or F: I am really tired of studying this shit

Answer 6

TRUE

Question 7

where are logan-gated ion channels located and what are they activated by?

Answer 7

located on cell surface and activated by neurotransmitters

Question 8

ligand-gated ion channels are usually composed of one or multiple subunits?

Answer 8

multiple

Question 9

what is an example of a logan-gated ion channel that we effect regularly in anesthesia?

Answer 9

nicotinic acetylcholine receptor—-succinylcholine

Question 10

what receptor type comprises a diverse array or activators and is the largest mammalian gene family?

Answer 10

GPCR

Question 11

what are beta-adrenergic receptors in the heart?

Answer 11

Single polypeptide chain spans the memberane 7 times, activates Gs to activate adenylate cyclase and make cyclic AMP

Question 12

what activates enzyme/cytokine receptors?

Answer 12

growth factors or cytokines

Question 13

homeboy is going wayyy too fast…

Answer 13

stopping on slide 15