Antipsychotics / Antidepressants

Question 1

What class of drugs:

block dopamine receptors
D2 family of dopamine receptors
Most block alpha₁, H₁, muscarinic, 5HT₂ receptors

Answer 1

antipsychotics

Question 2

What drugs: (2)

typical
expyramidal syndrome
block D₂
cause hyperprolactinemia

Answer 2

chlorpromazine

haloperidol

Question 3

What drug also block alpha₁ and 5HT₂ more than D₂?

Answer 3

chlorpromazine

Question 4

What drugs:

atypical
decreased incidence of extrapyramidal due to rapid dissociation of D₂ receptors
can reduce (+/-) symptoms somewhat

Answer 4

clozapine

aripiprazole

Question 5

What atypical drug:

binds to 5HT2 receptor
agranulocytosis up to 3%

Answer 5

clozapine

Question 6

What atypical drug:

partial agonist at D2 and 5HT1
antagonist at 5HT2
activate D2 at low tone and inhibit at high tone

Answer 6

apiprazole

Question 7

What is FDA approved for bipolar and schizophrenia?

Answer 7

apiprazole

Question 9

Tricyclic antidepressant

Answer 9

imipramine

Question 10

What drug:

not euphoric, dulling
unpleasant when given to non-depressed pt
patient compliance problems

Answer 10

imipramine

tricyclic

Question 11

What drug related to “amine hypothesis”?

Answer 11

imipramine

Question 12

What class is fluoxetine?

Answer 12

SSRI

aka prozac

Question 13

What drug:

dulling of depressive ideation
selective 5HT uptake inhibitor

Answer 13

fluoxetine

Question 14

What drug:

less antimuscarinic activity →
fewer cardiovascular issues
less pt compliance problems

Answer 14

fluoxetine

Question 15

What MAO-I is:

hydrazine?

nonhydrazine?

Answer 15

phenylzine

tranylcypromine

Question 16

What MAO-I is more of a psychomotor stimulant?

Answer 16

tranycypromine

Question 17

MAO-I →

____NE

____5HT

____DA

Answer 17

increases in all

Question 19

What drug class side effects include:

orthostatic hypotension
excessive CNS stimulation resulting in tremors
insomnia

Answer 19

MAO-I

Question 20

Side effects of overdose of MAO-I: (4)

Answer 20

agitation

hallucinations

hyperreflexia

convulsions

Question 21

What drug for acute mania and bipolar?

Answer 21

lithium

Question 22

What receptor does lithium inhibit?

Answer 22

GSK - 3B

glycogen synthase kinase - 3 beta

Question 23

What drug:

inositol phosphate metabolism
low margin of safety

Answer 23

lithium

Question 24

What drug:

antimanic
anti-epileptic

Answer 24

carbamazepine

valproate