Contraceptives

Question 1

What are estrogen only drugs? (3)

Answer 1

estradiol

estriol

estrone

Question 2

How do estrogen birth control pills work? (3)

Answer 2

reduce bone resorption

metabolic effect

pro-coagulatory

Question 3

What are the side effects of estrogen bc pills? (5)

Answer 3

fluid retention

tender breast

GI issue

migraine

endometrial cancer HRT

Question 4

How does progestin affect fertility? (2)

Answer 4

implantation

corpeus luteum

Question 5

Progesterone decreases fertility by: (2)

Answer 5

affecting basal body temp

endometrial and cervical secretions

Question 6

What are the side effects of progestin only pills? (2)

Answer 6

breakthrough bleeding

mild depression

Question 7

What are progestin only pills? (4)

Answer 7

minipill (norethindrone)

Depo-provera (medroxy)

Mirena (levono)

Implanon (etonogestrel)

Question 8

How are these progestin alone pills delivered?

Minipill

Depo-provera

Mirena

Implanon

Answer 8

oral daily

IM every 3 months

IUD for 5 years

implant under arm for 3 years

Question 9

What are the estrogen/progestin combo pills? (6)

Answer 9

seasonale

lunelle

nuva ring

ortho evra

lybrel

yaz

Question 10

What combo pill:

levon/estradiol
E/P: 1-84
period 1-4 times per year

Answer 10

Seasonale

Question 11

What combo pill:

estradiol/medroxy
injection every 28-33 days

Answer 11

Lunelle

Question 12

How long does the Nuvaring stay in?

Answer 12

3 weeks

Question 13

What combo BC:

estradiol/norelgestromin
patch ffor 7 days
3 weeks on/1 off
good only for <200 lb. women

Answer 13

Ortho Evra

Question 14

What combo BC:

coninuous levon/estradiol
NO period
increased risk of unrecognized pregnancy

Answer 14

Lybrel

Question 15

What combo BC:

synthetic progestin
drosprenone/estradiol

Answer 15

Yaz

Question 16

What combo BC:

can cause hyperkalemia
lead to fatal heart problems

Answer 16

YAZ

Question 17

What combo BC has most adverse side effects like:

DVT
embolism
stroke
MI
death
gall bladder injury

Answer 17

YAZ

Question 18

Why do we use progestin alone BC?

Answer 18

when estrogen is contraindicated

Question 19

What are post-coital drugs that are not effective if already pregnant?

Answer 19

Plan B (levono)

Preven (levono/estradiol)

Question 20

What is the fertility drug?

Answer 20

clomiphene

Question 21

How does clomiphene (fertility drug) work?

Answer 21

estrogen receptor antagonist to induce ovulation

Question 22

What is the abortion drug?

Answer 22

mifepristone

Question 23

How does mifepristone work?

Answer 23

antagonist of progesterone and glucocorticoid receptors

Question 24

What are selective estrogen receptor modulators (SERMs) which mimic the effects of estrogen in some organs but act as antagonists in others? (2)

Answer 24

tamoxifen

raloxifene

Question 25

What SERM is estrogen antagonist in breast tissue and inhibits proliferation of breast cancer?

Answer 25

tamoxifen

Question 26

What SERM is an estrogen antagonist in breast and uterine agonist in bone good for osteoporosis?

Answer 26

raloxifene

Also decreases risk of invasive breast cancer.

Question 27

What drug is anti cancer based on inhibition of estrogen synthesis and is first line drug for breast cancer?

Answer 27

femara