Opioid Analgesics

Question 1

What drug class is most effective in relief of severe pain?

What drugs are within this class?

Answer 1

strong opioid agonist

morphine, methadone

Question 2

What are the opioid receptors? (3)

Answer 2

mu

delta

kappa

Question 3

What drug class can reverse the coma and respiratory depression caused by morphine overdose?

Name the drugs within this class.

Answer 3

opioid antagonists

Narcan, Naltrexone

Question 4

Strong opioid agonists have a high affinity for ___ receptors.

Answer 4

mu

Question 5

What is a moderate opioid agonist?

Answer 5

codeine

Question 6

What are mixed opioid agonist-antagonist drugs also known as partial agonists.

Note: partial agonists are used to produce a submaximal response.

Answer 6

pentazocine

buprenorphine

Question 7

What is the advantage to using mixed opioid agonist-antagonists?

Answer 7

good for lowering abuse potential for drug abusers

Question 8

Which drug class is often used in combination with non-opioid analgesics for the treatment of moderate pain?

Answer 8

moderate opioid agonist, codeine

Question 9

Pentazocine is a drug for what drug abusers?

What is it an agonist for?

What is it an antagonist for?

Answer 9

morphine

k agonist

mu antagonist

Question 10

Buprenophine is a drug good for what type of drug abusers?

Answer 10

mu agonist

kappa antagonist

coke and heroin abuse

Question 11

What drug is good for severe pain, MI, and cancer?

10% opium

Answer 11

strong opioid agonist, morphine

Question 12

What drug is:

metabolized to morphine

combined with aspirin and acetominophen

added to cough syrups

for moderate pain

Answer 12

codeine

tramadol