3S [LEC]: Fibrinolytic System Flashcards
(7 cards)
1
Q
The final stage of hemostatic activation
A
Fibrinolysis
2
Q
The systematic, accelerating hydrolysis of fibrin by plasmin
A
Fibrinolysis
3
Q
Intrinsic activators of fibrinolytic system
A
XIIa, Kallikrein, HMWK
4
Q
Free plasmin can be found in the circulation and is capable of digesting plasma fibrinogen, fibronectin, and which coagulation factor/s?
A
V, VIII
5
Q
A major fibrinolysis inhibitor that rapidly binds and inactivates free plasma
A
a2-antiplasmin
6
Q
A condition that occurs when free plasmin circulates unchecked, breaking down fibrinogen and formed fibrin clots
A
Primary fibrinolysis
7
Q
The principal inactivator of plasminogen that TPA and UPA, preventing them from converting plasminogen to the active fibrinolytic enzyme plasmin
A
PAI-1 (plasminogen activator inhibitor-1)
