3S [LEC]: Secondary Hemostasis

Question 1

Extrinsic pathway starts with the release of ___ from injured blood vessels

Answer 1

Tissue factor (factor III)

Question 2

Intrinsic pathway is activated when coagulation proteins are exposed to ___

Answer 2

Collagen

Question 3

The goal of secondary hemostasis is the generation of sufficient ___ to convert fibrinogen to fibrin

Answer 3

Thrombin (factor IIa)

Question 4

Coagulation pathway that is dominant in vivo

Answer 4

Extrinsic pathway

Question 5

Common pathway begins with ___ activation by the extrinsic or intrinsic pathway

Answer 5

Factor X

Question 6

T/F: Coagulation factors can be used as a secondary test for liver function

Answer 6

True

Question 7

Coagulation factors are produced mostly in the ___, and circulate in an active precursor form

Answer 7

Liver

Question 8

Coagulation factors are also known as ___

Answer 8

Zymogens (enzyme precursors)

Question 9

Zymogens are converted into active forms called ___ to possess biologic activity

Answer 9

Serine proteases

Question 10

The only electrolyte that is an activator in blood coagulation

Answer 10

Ca2+ (factor IV)

Question 11

Which factor is converted into transglutaminase instead of serine protease when activated?

Answer 11

Factor XIII

Question 12

The only substrate in the cascade that does not become an activated enzyme

Answer 12

Fibrinogen (factor II) (converted into fibrin)

Question 13

T/F: Factor XII deficiency will cause a bleeding condition

Answer 13

False (thrombotic condition)

Question 14

Which factors are part of the intrinsic pathway?

Answer 14

XII, XI, IX, VIII

Question 15

Which factor/s is/are part of the extrinsic pathway?

Answer 15

VII

Question 16

Which factors are part of the common pathway?

Answer 16

X, V, II, I

Question 17

In the common pathway, which factor will convert factor Xa to factor II?

Answer 17

V

Question 18

Most abundant coagulation factor

Answer 18

Factor I

Question 19

Factors that are part of the fibrinolytic system

Answer 19

XII, Prekallikrein, HMWK

Question 20

Aside from factor XIa, which factor may also activate factor IX?

Answer 20

Factor VII

Question 21

Which factor converts factor IX, to factor X?

Answer 21

Factor VIII

Question 22

This factor is activated by factor XIIa, which also activates factor XII once activated

Answer 22

Prekallikrein (activated to Kallikrein, which will activate factor XII)

Question 23

This factor will help in the activation of prekallikrein to kellikrein

Answer 23

HMWK

Question 24

Identify the coagulation factor based on its common/ other name:

Contact factor

Answer 24

Factor I

Question 25

Identify the coagulation factor based on its common/ other name: Glass factor

Answer 25

Factor I

Question 26

Identify the coagulation factor based on its common/ other name: Hageman factor

Answer 26

Factor I

Question 27

Identify the coagulation factor based on its common/ other name: Fletcher factor

Answer 27

Prekallikrein

Question 28

Identify the coagulation factor based on its common/ other name: Fitzgerald factor

Answer 28

HMWK

Question 29

Identify the coagulation factor based on its common/ other name: Williams factor

Answer 29

HMWK

Question 30

Identify the coagulation factor based on its common/ other name: Flaujeac factor

Answer 30

HMWK

Question 31

Identify the coagulation factor based on its common/ other name: Antihemophilia factor C

Answer 31

Factor XI

Question 32

Identify the coagulation factor based on its common/ other name: Rosenthal factor

Answer 32

Factor XI

Question 33

Identify the coagulation factor based on its common/ other name: Plasma thromboplastin antecedent

Answer 33

Factor XI

Question 34

Identify the coagulation factor based on its common/ other name: Antihemophilia B factor

Answer 34

Factor IX

Question 35

Identify the coagulation factor based on its common/ other name: Christmas factor

Answer 35

Factor IX

Question 36

Identify the coagulation factor based on its common/ other name: Plasma thromboplastin component

Answer 36

Factor IX

Question 37

Identify the coagulation factor based on its common/ other name: Antihemophilia A factor

Answer 37

Factor VIII

Question 38

Identify the coagulation factor based on its common/ other name: Stable factor

Answer 38

Factor VII

Question 39

Identify the coagulation factor based on its common/ other name: Proconvertin

Answer 39

Factor VII

Question 40

Identify the coagulation factor based on its common/ other name: Stuart-prower factor

Answer 40

Factor X

Question 41

Identify the coagulation factor based on its common/ other name: Labile factor

Answer 41

Factor V

Question 42

Identify the coagulation factor based on its common/ other name: Proaccelerin

Answer 42

Factor V

Question 43

Identify the coagulation factor based on its common/ other name: Prothrombin/ Prethrombin

Answer 43

Factor II

Question 44

Identify the coagulation factor based on its common/ other name: Fibrinogen

Answer 44

Factor I

Question 45

Deficiency of this factor may cause Owren disease

Answer 45

Factor V

Question 46

Identify the coagulation factor based on its common/ other name: Fibrin stabilizing factor

Answer 46

Factor XIII

Question 47

Identify the coagulation factor based on its common/ other name: Laki-Lorand factor

Answer 47

Factor XIII

Question 48

Identify the coagulation factor based on its common/ other name: Ca2+

Answer 48

Factor IV

Question 49

Identify the coagulation factor based on its common/ other name: Tissue factor

Answer 49

Factor III

Question 50

Identify the coagulation factor based on its common/ other name: Thromboplastin

Answer 50

Factor III

Question 51

Most concentrated coagulation protein

Answer 51

Factor I

Question 52

Coagulation factors activated at cold temperature

Answer 52

Factor VII, Factor XI

Question 53

Labile coagulation factors

Answer 53

Factor V, Factor VIII

Question 54

Deficiency for this factor will not cause bleeding, but would cause poor wound healing conditions

Answer 54

Factor XIII