Antigen processing and presenting Flashcards

1
Q

Where is MHC 2 found

A

Only on APC cells

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2
Q

What are the three professional APC

A

Dendritic cell
B Cell
Macrophage

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3
Q

What are some characteristics of dendritic cells

A

Best APC
only one that can stimulate naive cell
Regulate both innate and acquired immune systems
Can take up many different antigens

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4
Q

Where do dendritic cells come from

A

bone marrow

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5
Q

What makes an immature DC into a mature DC

A

antigen

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6
Q

What is proteolysis

A

protein degradation

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7
Q

What is phagolysosome

A

digestive enzymes in the lysosome

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8
Q

Where are antigens presented

A

MHC-peptide complex on cell surface

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9
Q

How do we uptake endogenous antigen

A

Sample of intracellular proteins

Viruses, intracellular bacteria

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10
Q

How does degradation of endogenous antigens happen

A

Ubiquitin-chaperone protein, brings protein to the proteosome
Proteosome- group of enzymes that digest proteins

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11
Q

What is the complex formation of endogenous antigens

A

MHC class 1

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12
Q

What is the presentation of endogenous antigens

A

MHC class 1 on all nucleated cells

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13
Q

What are processed and presented on MHC class 1

A

all intraceytoplasmic proteins

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14
Q

What recognizes foregin MHC 1

A

CD8 cytotoxic T cells

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15
Q

What do NK cells recognize on cell and what happens

A

Lack of MHC 1, if there is none it is killed by NK

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16
Q

What causes the uptake of exogenous antigen

A

Phagocytosis, endocytosis, BCR-mediated

17
Q

What does MHC 2 present on

A

only on antigen presenting cells

18
Q

What does MHC class 2 cells do

A

presents a sampling of the proteins outside of the cell

19
Q

What recognizeses MHC class 2 cells

A

CD4 helper T cells

20
Q

What does MHC class 2 activate

A

acquired immune system

21
Q

Is MHC 2 stable without an antigen

A

No

22
Q

What recognizes MHC class 1

A

CD8

23
Q

Is MHC stable without antigen

A

no

24
Q

Endogenous vs Exogenous

A

Endogenous: All nuc. cells, intracellular antigen, virus, proteozome, Ag loading on ER, MHC 1, CD8 T-cell

Exogenous: Only on APC, extracellular antigen, bacteria, fungus protozoa, phagolysosome, Ag loading in phagolysosome, MHC 2, CD4 T-cell

25
Q

What is the “rule of 8”

A

MHC 1 goes with CD8 T-cell
MHC 2 goes with CD4 T-cell

1x8=8
2x4=8

26
Q

What do CD4 T cells do if they make IL-2, IFN-gamma

A

If they do this they are Th1

They just help, don’t do any of the work

27
Q

What does a Th1 response do

A

Stimulate cell mediated killing

CD8 cytotoxic T cell does the killing

28
Q

What does CD4 T cells that make IL-4, IL-5 do

A

Th2

Stimulate humoral response (B-cells)

29
Q

What do effector cells do

A

Surveying for infected cells and killing or producing antibody

30
Q

Characteristics of CD8 T cells (cytotoxic effector cells)

A

Intracellular antigens

Recognize MHC 1

31
Q

What causes the exogenous degredation

A

phagolysosome

32
Q

What is the complex formation of exogenous antigen

A

MHC 2

Loaded in phagolysosome

33
Q

How is exogenous antigen presented

A

MHC 2 only on APC

34
Q

How do APC’s function by

A

Internalizing antigen
Digesting antigen
Display peptide Ag bound to MHC 2