6 Antigen Presenting Cells

Question 1

What are the three types of Antigen Presenting Cells?

Answer 1

Dendritic Cells
Macrophages
B Cells

Question 2

Where does activation of naive T cells exclusively occur?

Answer 2

Secondary Lymph

Question 3

What two signals are required for T cell activation?

Answer 3

MHC:peptide

B7 binding to CD28 (costimulation)

Question 4

What class of immune cell only expresses B7 signal?

Answer 4

APCs

Question 5

What are lectins that bind to carbohydrates?

Answer 5

Selectins

Question 6

What are mucin like vascular addressins?

Answer 6

Adhesion molecules that target carbohydrates

Question 7

What is an example of an integrin?

Answer 7

LFA- (lymphocyte function adhesion molecule 1)

Question 8

What are targets for integrin binding?

Answer 8

Immunoglobulin superfamily receptors

ICAMs, CD2, LFA3

Question 9

What do naive T cells depend on to bind to endothelial walls?

Answer 9

CD34 on endothelium to bind to

Question 10

What binds to CD34 on high endothelial walls?

Answer 10

L-selectin

Question 11

What is the first adhesive molecule pairing to occur in Naive T cell diapedesis?

Answer 11

GlyCAM1 and CD34

Question 12

What is the second, tightening, adhesive molecule paring to occur in Naive T cell diapedesis?

Answer 12

LFA1 binding to ICAM1 on endothelium (cytokine activated)

Question 13

What is diapedesis?

Answer 13

Lymphocyte movement from blood into lymph

Question 14

Where do activated T cells go?

Answer 14

Inflammatory sites

Question 15

Why do we not want activated T cells in secondary lymph?

Answer 15

They will destroy good tissue

Question 16

What prevents CD8 cells from re-entering secondary lymph?

Answer 16

They do not express L selectin

Question 17

What do activated CD8 cells express to bind them to activated endothelium?

Answer 17

LFA1
VLA4
to bind to endothelial VCAM1

Question 18

Where are dendritic cells located in the lymph node?

Answer 18

T cell areas

Question 19

Where are B cells located in the lymph node?

Answer 19

Follicles

Question 20

How do dendritic cells take up antigen?

Answer 20

Macropinocytosis
Phagocytosis
Viral Infection

Question 21

How do macrophages take up antigen?

Answer 21

Phagocytosis

Question 22

How do B cells take up antigen?

Answer 22

Ig-Receptor Antigen specific binding

Question 23

What does MHC expression look like in Dendritic Cells?

Answer 23

Low on tissue DCs
High on lymph DCs
Viral An presented

Question 24

What does MHC expression look like in Macrophages?

Answer 24

Bacterial and Cytokine presentation

Question 25

What does MHC expression look like in B cells?

Answer 25

Increase with activation???

Question 26

What An do DCs present?

Answer 26

Viral Allergens (peptides)

Question 27

What an to macrophages present?

Answer 27

Bacteria | virus and particulate second

Question 28

What An to B cells present?

Answer 28

Toxins | virus and soluble antigens

Question 29

What cell is only mainly found in the Lymph?

Answer 29

B call

Question 30

What cell goes back to the bone marrow following activation?

Answer 30

Plasma B Cell

Question 31

What cell type makes the most B7 of APCs?

Answer 31

Dendritic Cells

Question 32

What cell type is mainly for intracellular infections?

Answer 32

Dendritic Cells

Question 33

What are DCs in dermis of skin?

Answer 33

Langerhan cells

Question 34

What is typical of mature Dedritic cells?

Answer 34

B7 production High MHC I and II levels Chemotractant to promote sampling

Question 35

What is typical of immature Dendritic cells?

Answer 35

``` NO b7 Expressed Epithelium PAMPs Some MHC Complement receptors LFA adhesion molecules still expressed ```