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Flashcards in 4 MHC Deck (18):
1

How many chains are in the Class I MHC structure and what are they called?

Alpha
Beta2 Microglobulin (not in MHC gene)

2

What does the active site of MHC I look like?

Cleft closed at both ends

3

What does the active site of MHC II look like?

Cleft open at both ends

4

What is the range of peptide size for MHC class I?

8-10

5

What is the range of peptide size for MHC II?

13+
More promiscuous and larger antigens bound

6

What route within the cell produces MHC I antigen presentation?

Cytosolic
Proteosome

7

What route within the cell presents MHC II antigen presentation?

Endosome
MHC:
1. Invariant chain
2. Clip protein portion
3. HLA-DM clip removal
4. antigen binding to site

8

What cell recognizes MHC I?

CD8+ T Cells

9

What do CD8+ T cells cells do?

Kill infected cell

10

What cell recognizes MHC II?

CD4 T cell

11

What do CD4+ T cells do?

Help orchestrat B cell activation "helper T cell"

12

What cells are MHC II found on?

APCs

13

Where do MHC II help in T cell maturation?

Cortex of thymus

14

What do MHCI presentations typically mean?

Virus infection!

15

How many alleles do MHC I genes have?

3: ABC

16

How many alleles to MHC II genes have?

3: DP, DQ, DR

17

What is the most variable MHC II allele?

DR, has 2 loci

18

How does the polymorphism of MHC genes affect immunity?

Variety of alleles allows variety of response, increasing immunity response potential