Flashcards in 4 MHC Deck (18):
How many chains are in the Class I MHC structure and what are they called?
Beta2 Microglobulin (not in MHC gene)
What does the active site of MHC I look like?
Cleft closed at both ends
What does the active site of MHC II look like?
Cleft open at both ends
What is the range of peptide size for MHC class I?
What is the range of peptide size for MHC II?
More promiscuous and larger antigens bound
What route within the cell produces MHC I antigen presentation?
What route within the cell presents MHC II antigen presentation?
1. Invariant chain
2. Clip protein portion
3. HLA-DM clip removal
4. antigen binding to site
What cell recognizes MHC I?
CD8+ T Cells
What do CD8+ T cells cells do?
Kill infected cell
What cell recognizes MHC II?
CD4 T cell
What do CD4+ T cells do?
Help orchestrat B cell activation "helper T cell"
What cells are MHC II found on?
Where do MHC II help in T cell maturation?
Cortex of thymus
What do MHCI presentations typically mean?
How many alleles do MHC I genes have?
How many alleles to MHC II genes have?
3: DP, DQ, DR
What is the most variable MHC II allele?
DR, has 2 loci