5 T Cell Diversity and Development Flashcards Preview

Immunology Test 1 > 5 T Cell Diversity and Development > Flashcards

Flashcards in 5 T Cell Diversity and Development Deck (39):
1

Where is a T cell made?

Bone Marrow

2

Where does a T cell mature?

Thymus

3

Where does a T cell live?

Secondary Lymph

4

What does a T cell derive from?

Common lymphoid precursor

5

What type of single antigen is recognized by a T cell?

peptide antigen in context with MHC

6

What cells does a T cell help activate?

Macrophage
CD4 Helper T cell

7

What are the 2 types of T cell lineage TCRs?

AB and yD

8

What is different about AB T cells?

Thymic development
Peptide recognized
MHC restricted

9

What is different about yD T cells?

Mucosal epithelium location
Lipid recognized
Non thymic development
Non-MHC restricted

10

What do CD3 surface markers do?

Signal transduction

11

What relies on CD3?

T cell activation

12

What is an ITAMs?

immunoreceptor tyrosine-based activation motifs in CD3 TCRs

13

What are CD4 and CD8?

Coreceptors for TCRs
All mature T cells have one or the other

14

What are structural differences between CD4 and CD8?

CD4 is a single chain
CD8 is a heterodimer

15

What MHC class does CD4 recognize?

MHC II

16

What MHC class does CD8 recognize

MHC I

17

What antigen type is the MHC II pathway used for?

Extracellular pathogens

18

What antigen type is the MHC I pathway used for?

Intracellular pathogens

19

What is CD28 used for?

Costimulation of T cells
Binds B7 molecules from APCs

20

What is Fas ligand used for?

Apoptotic pathway

21

What is the meta organization of the thymus?

Cortex
Medullary region

22

Where does positive T cell selection occur?

Thymus cortex

23

Where does negative T cell selection occur?

Medullary region
Hassal's corpuscle

24

What is the first step in T cell maturation in the thymus?

MHC is presented by cortical cells

25

What is the second step in T cell maturation in the thymus?

Somatic recombination

26

What is the overview of T cell maturation?

Somatic recombination
Positive selection
Negative selection

27

What is the first chain of the TCR to begin adapting to maturation signals?

Beta chain genes

28

What happens in T cell maturation after AB chain recombination?

Expression of CD3, then CD4 aaaand CD8

29

When CD4/8 is produced on T cells, what occurs?

Positive selection of MHC I/II in the cortex

30

What is downregulated as the T cell moves into the medullary region?

The unused CD4/8

31

What is destroyed in the medullary region?

Self recognizing T cells

32

How does a T cell become a yD TCR?

If y or D are expressed first

33

How does a T cell become a AB TCR?

1. B chain expressed
2. Invariant chain (pTalpha) transcribed and binds
3. Pre-T cell receptor combines with the CD3 complex
4. AB TCR rearrangement (full A chain made)
5. CD4/8 production
6. CD4/8 selection
7. Migration to 2* lymph

34

What occurs in alpha chain gene recombination ?

Random
1. VJ region brought together
2. Transription
3. C region spliced to be proximal
4. Translation

35

What occurs in B chain gene recombination?

Random
1. VDJ region joined
2. Transcription
3. C region spliced to be proximal
4. Translation

36

What T cell tumor would express CD34?

T cell tumor of Bone Marrow stem cell origin

37

What T cell tumor would express CD10,19, 20?

T cell tumor of Thymus progenitor cell origin

38

What T cell tumor would express CD1?

T cell tumor of Thymus developing cell origin

39

What T cell tumor would express CD3, CD4/8, or TCRs?

T cell tumor of peripheral origin from mature T cell