5 T Cell Diversity and Development

Question 1

Where is a T cell made?

Answer 1

Bone Marrow

Question 2

Where does a T cell mature?

Answer 2

Thymus

Question 3

Where does a T cell live?

Answer 3

Secondary Lymph

Question 4

What does a T cell derive from?

Answer 4

Common lymphoid precursor

Question 5

What type of single antigen is recognized by a T cell?

Answer 5

peptide antigen in context with MHC

Question 6

What cells does a T cell help activate?

Answer 6

Macrophage

CD4 Helper T cell

Question 7

What are the 2 types of T cell lineage TCRs?

Answer 7

AB and yD

Question 8

What is different about AB T cells?

Answer 8

Thymic development
Peptide recognized
MHC restricted

Question 9

What is different about yD T cells?

Answer 9

Mucosal epithelium location
Lipid recognized
Non thymic development
Non-MHC restricted

Question 10

What do CD3 surface markers do?

Answer 10

Signal transduction

Question 11

What relies on CD3?

Answer 11

T cell activation

Question 12

What is an ITAMs?

Answer 12

immunoreceptor tyrosine-based activation motifs in CD3 TCRs

Question 13

What are CD4 and CD8?

Answer 13

Coreceptors for TCRs

All mature T cells have one or the other

Question 14

What are structural differences between CD4 and CD8?

Answer 14

CD4 is a single chain

CD8 is a heterodimer

Question 15

What MHC class does CD4 recognize?

Answer 15

MHC II

Question 16

What MHC class does CD8 recognize

Answer 16

MHC I

Question 17

What antigen type is the MHC II pathway used for?

Answer 17

Extracellular pathogens

Question 18

What antigen type is the MHC I pathway used for?

Answer 18

Intracellular pathogens

Question 19

What is CD28 used for?

Answer 19

Costimulation of T cells

Binds B7 molecules from APCs

Question 20

What is Fas ligand used for?

Answer 20

Apoptotic pathway

Question 21

What is the meta organization of the thymus?

Answer 21

Cortex

Medullary region

Question 22

Where does positive T cell selection occur?

Answer 22

Thymus cortex

Question 23

Where does negative T cell selection occur?

Answer 23

Medullary region

Hassal’s corpuscle

Question 24

What is the first step in T cell maturation in the thymus?

Answer 24

MHC is presented by cortical cells

Question 25

What is the second step in T cell maturation in the thymus?

Answer 25

Somatic recombination

Question 26

What is the overview of T cell maturation?

Answer 26

Somatic recombination Positive selection Negative selection

Question 27

What is the first chain of the TCR to begin adapting to maturation signals?

Answer 27

Beta chain genes

Question 28

What happens in T cell maturation after AB chain recombination?

Answer 28

Expression of CD3, then CD4 aaaand CD8

Question 29

When CD4/8 is produced on T cells, what occurs?

Answer 29

Positive selection of MHC I/II in the cortex

Question 30

What is downregulated as the T cell moves into the medullary region?

Answer 30

The unused CD4/8

Question 31

What is destroyed in the medullary region?

Answer 31

Self recognizing T cells

Question 32

How does a T cell become a yD TCR?

Answer 32

If y or D are expressed first

Question 33

How does a T cell become a AB TCR?

Answer 33

1. B chain expressed 2. Invariant chain (pTalpha) transcribed and binds 3. Pre-T cell receptor combines with the CD3 complex 4. AB TCR rearrangement (full A chain made) 5. CD4/8 production 6. CD4/8 selection 7. Migration to 2* lymph

Question 34

What occurs in alpha chain gene recombination ?

Answer 34

Random 1. VJ region brought together 2. Transription 3. C region spliced to be proximal 4. Translation

Question 35

What occurs in B chain gene recombination?

Answer 35

Random 1. VDJ region joined 2. Transcription 3. C region spliced to be proximal 4. Translation

Question 36

What T cell tumor would express CD34?

Answer 36

T cell tumor of Bone Marrow stem cell origin

Question 37

What T cell tumor would express CD10,19, 20?

Answer 37

T cell tumor of Thymus progenitor cell origin

Question 38

What T cell tumor would express CD1?

Answer 38

T cell tumor of Thymus developing cell origin

Question 39

What T cell tumor would express CD3, CD4/8, or TCRs?

Answer 39

T cell tumor of peripheral origin from mature T cell