Flashcards in 11 Principles of Innate Immunity Deck (28):
What are the five types of infectious pathogens?
What innate immune response is best at dealing with extracelluar pathogens?
Ab neutralization (via B1 cells)
What innate immune cells are best at dealing with cytoplasmic infection?
CD8 and NK cells
What innate immune cells are best at dealing with vesicular infection?
T cell activated macrophages
What are the innate immune cells?
Macrphages, Neutrophils, NK cells
What are the main innate defenses?
Physical (Mechainical, Chemical, Microbial) Barriers
Complement (Alternative and Lectin Pathways
Macrophages and Neutrophils
What are the chemical barriers of the innate immune response?
proteins: cryptidins, defensins, amphipathic peptides, lysozymes
What innate defense enzyme is secreted in spit and tears?
What innate defense enzyme is inserted into bacterial outer envelopes?
What is the C3 convertase of the alternative pathway?
What is the C3 convertase of the Classical pathway?
What is special about complement markings?
Complement binding is permanent
What are the complement regulating enzymes?
CD59 (binds MAC)
Factor I (Degrades C3b)
What do macrophages kill with?
ROS (NO is also a ROS)
Competitors (Lactoferrin binds iron, B12 binding protein)
What macrophage produced enzyme binds iron?
What macrophage produced enzyme effects the major metabolism coenzyme of cells?
B12 binding protein
(reason sensory loss after infection: dorsal root ganglia have lowered coenzyme availability and sensory nerves misfire)
What cells are the first to arrive in the inflammatory response?
What cells signal Neutrophil release from the bone marrow?
Macrophages and NK cells
What enzyme is involved in producing the oxidative burst?
NADPH dependent oxidase
What are the three types of PRRs and what are their overview functions?
Endocytic PRRs: Clean up dead cells carbs.
Signalling PRRs: Sensors for cytokine production
Secreted PRRs: Complement Proteins
What are two secreted complement protein PRRs?
C reactive protein (Alternative path, Cq binds)
Mannose binding protein (Lectin pathway)
How many hours after pathogen infestation does it take for early adaptive responses to occur?
usually 4 hours
What is the overview point of early adaptive responses?
Control of infection
TNFa makes clotting of region, inflammation sets in, migration begins
What are the markers of acute phase response?
B1 cell antibodies form
What are the main cells that control viral infections?
CD8 T cells
What activates NK cells?
IFNa and b (class I IFNs)
What do Class one IFNs do?
Reduce neighbor cell susceptibility
Activate NK cells
Upregulate MHC class I expression