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Flashcards in 6 Antigen Presenting Cells Deck (35):
1

What are the three types of Antigen Presenting Cells?

Dendritic Cells
Macrophages
B Cells

2

Where does activation of naive T cells exclusively occur?

Secondary Lymph

3

What two signals are required for T cell activation?

MHC:peptide
B7 binding to CD28 (costimulation)

4

What class of immune cell only expresses B7 signal?

APCs

5

What are lectins that bind to carbohydrates?

Selectins

6

What are mucin like vascular addressins?

Adhesion molecules that target carbohydrates

7

What is an example of an integrin?

LFA- (lymphocyte function adhesion molecule 1)

8

What are targets for integrin binding?

Immunoglobulin superfamily receptors
(ICAMs, CD2, LFA3)

9

What do naive T cells depend on to bind to endothelial walls?

CD34 on endothelium to bind to

10

What binds to CD34 on high endothelial walls?

L-selectin

11

What is the first adhesive molecule pairing to occur in Naive T cell diapedesis?

GlyCAM1 and CD34

12

What is the second, tightening, adhesive molecule paring to occur in Naive T cell diapedesis?

LFA1 binding to ICAM1 on endothelium (cytokine activated)

13

What is diapedesis?

Lymphocyte movement from blood into lymph

14

Where do activated T cells go?

Inflammatory sites

15

Why do we not want activated T cells in secondary lymph?

They will destroy good tissue

16

What prevents CD8 cells from re-entering secondary lymph?

They do not express L selectin

17

What do activated CD8 cells express to bind them to activated endothelium?

LFA1
VLA4
to bind to endothelial VCAM1

18

Where are dendritic cells located in the lymph node?

T cell areas

19

Where are B cells located in the lymph node?

Follicles

20

How do dendritic cells take up antigen?

Macropinocytosis
Phagocytosis
Viral Infection

21

How do macrophages take up antigen?

Phagocytosis

22

How do B cells take up antigen?

Ig-Receptor Antigen specific binding

23

What does MHC expression look like in Dendritic Cells?

Low on tissue DCs
High on lymph DCs
Viral An presented

24

What does MHC expression look like in Macrophages?

Bacterial and Cytokine presentation

25

What does MHC expression look like in B cells?

Increase with activation???

26

What An do DCs present?

Viral
Allergens
(peptides)

27

What an to macrophages present?

Bacteria
(virus and particulate second)

28

What An to B cells present?

Toxins
(virus and soluble antigens)

29

What cell is only mainly found in the Lymph?

B call

30

What cell goes back to the bone marrow following activation?

Plasma B Cell

31

What cell type makes the most B7 of APCs?

Dendritic Cells

32

What cell type is mainly for intracellular infections?

Dendritic Cells

33

What are DCs in dermis of skin?

Langerhan cells

34

What is typical of mature Dedritic cells?

B7 production
High MHC I and II levels
Chemotractant to promote sampling

35

What is typical of immature Dendritic cells?

NO b7 Expressed
Epithelium
PAMPs
Some MHC
Complement receptors
LFA adhesion molecules still expressed