Flashcards in 6 Antigen Presenting Cells Deck (35):
What are the three types of Antigen Presenting Cells?
Where does activation of naive T cells exclusively occur?
What two signals are required for T cell activation?
B7 binding to CD28 (costimulation)
What class of immune cell only expresses B7 signal?
What are lectins that bind to carbohydrates?
What are mucin like vascular addressins?
Adhesion molecules that target carbohydrates
What is an example of an integrin?
LFA- (lymphocyte function adhesion molecule 1)
What are targets for integrin binding?
Immunoglobulin superfamily receptors
(ICAMs, CD2, LFA3)
What do naive T cells depend on to bind to endothelial walls?
CD34 on endothelium to bind to
What binds to CD34 on high endothelial walls?
What is the first adhesive molecule pairing to occur in Naive T cell diapedesis?
GlyCAM1 and CD34
What is the second, tightening, adhesive molecule paring to occur in Naive T cell diapedesis?
LFA1 binding to ICAM1 on endothelium (cytokine activated)
What is diapedesis?
Lymphocyte movement from blood into lymph
Where do activated T cells go?
Why do we not want activated T cells in secondary lymph?
They will destroy good tissue
What prevents CD8 cells from re-entering secondary lymph?
They do not express L selectin
What do activated CD8 cells express to bind them to activated endothelium?
to bind to endothelial VCAM1
Where are dendritic cells located in the lymph node?
T cell areas
Where are B cells located in the lymph node?
How do dendritic cells take up antigen?
How do macrophages take up antigen?
How do B cells take up antigen?
Ig-Receptor Antigen specific binding
What does MHC expression look like in Dendritic Cells?
Low on tissue DCs
High on lymph DCs
Viral An presented
What does MHC expression look like in Macrophages?
Bacterial and Cytokine presentation
What does MHC expression look like in B cells?
Increase with activation???
What An do DCs present?
What an to macrophages present?
(virus and particulate second)
What An to B cells present?
(virus and soluble antigens)
What cell is only mainly found in the Lymph?
What cell goes back to the bone marrow following activation?
Plasma B Cell
What cell type makes the most B7 of APCs?
What cell type is mainly for intracellular infections?
What are DCs in dermis of skin?
What is typical of mature Dedritic cells?
High MHC I and II levels
Chemotractant to promote sampling