Cytokines Flashcards Preview

Immunology Test 1 > Cytokines > Flashcards

Flashcards in Cytokines Deck (20):
1

IL-1 (alpha, beta)

stimulates IL-2 receptor emergence in T cells
Enhances B cell activation
Induces fever, acute phase reactants, and IL-6

2

IL-2

T cell growth factor
Activates NK and B cells

3

IL-3

Stimulates hematopoiesis

4

IL-4

Stimulates B cell synthesis of IgE
Down regulates IFN-gamma

5

IL-5

Stimulates growth and differentiation of eosinophils
B cell growth factor
Enhances IgA synthesis

6

IL-6

Induces acute phase reactants, fever, and late B cell differentiation

7

IL-7

Stimulates pre-B and pre-T cells

8

IL-8

Chemotactic factor for neutrophils and T cells

9

IL-9

Cell mitogen

10

IL-10

Inhibits IFN-gamma synthesis by TH1 cells
Suppresses other cytokine synthesis

11

IL-11

Stimulates hematopoiesis
Enhances acute phase protein synthesis

12

IL-12

Promotes TH1 differentiation and IFN-gamma synthesis
Stimulates NK cells and CD8+ T cells to ctolysis
Acts synergistically with IL-2

13

IL-13

Inhibits inflammatory cytokines

14

IL-15

T cell mitogen
Enhances growth of intestinal epithlium

15

IL-16

Increases class II MHC, chomtaxis, and CD4+ T cell cytokines
Decreases antigen induced proliferation

16

IL-17

Increases the inflammatory response

17

IL-18

Increases IFN-gamma production and NK cel activation

18

TNF-alpha

Cytotoxic for tumors
Causes cachexia
Mediates bacterial shock

19

TNF-beta

Cytotoxic for tumors

20

TGF-beta

Inhibits proliferation of both T and B cells
Reduces cytokine receptors
Potent chemotactic agent for leukocytes
Mediates inflammation and tissue repair