September 30, 2015 - T Cell Physiology

Question 1

Variable Region

Answer 1

Binds the antigen.

Question 2

T Cell Selection

Answer 2

Occurs in the Thymus.

Very few cells actually “graduate” the thymus. TCRs that can’t interact with self MHC molecules are destroyed, and TCRs that are too attracted to self MHC are destroyed.

Question 3

Subsets of CD4 T Cells

Answer 3

TH1 - Intracellular microorganisms

TH2 - Parasitic infections

TH17 - Extracellular bacteria and fungi

Treg - Tolerance

Question 4

TH1 Cells

Answer 4

Important for stimulating macrophages and stimulating antibody production.

Important for the ingestion and killing of INTRAcellular microbes.

Question 5

TH2 Cells

Answer 5

Stimulates the production of IgE antibodies as well as activating eosinophils.

Helpful for fighting helminth parasites.

Question 6

TH17 Cells

Answer 6

Capable of recruiting neutrophils and causing inflammation. Also are implicated for their role in autoimmune diseases.

Question 7

Treg Cells

Answer 7

Immunosuppressive cells.

Question 8

Central Tolerance

Answer 8

Learned in Thymus.

Question 9

Peripheral Tolerance

Answer 9

When mature T cells recognize self-antigens in peripheral tissues (that weren’t in the Thymus). Inactivation of the cell occurs normally.

Question 10

Autoimmunity

Answer 10

The loss of immunological tolerance.