Antivirals Flashcards
Name some RNA viruses
Influenza
HIV
Hepatitis C
What is influenza A?
Birds and some mammals
Antigenic drift and shift
Seasonal epidemic
Pandemic potential
What is Influenza B?
No animal reservoir
Lower mortality
What is Influenza C?
Like the common cold
What are some high risk groups for Influenza?
Elderly
Airway and Cardiac Diseases
Diabetes
Renal failure
Explain the life cycle of a virus
Gets absorbed into host cell by Endocytosis
Transported through cytoplasm in an endosomal vesicle
Vesicle is uncoated
RNA replication and synthesis of viral proteins
Assembly of RNA and viral protein
Budding of new particle out of cell
Release
How do Amantanades work?
M2 ion channel blocker
M2 channel is needed to transport protons into virion
This disintegrates the virion and allows RNA replication and viral protein synthesis
By blocking it, you stop the virion from disintegrating
What does Amantanade work on?
Influenza A only
What are ADRs of Amantanades?
CNS effects
Renal effects
How does Neuraminidase work in viral replication?
Allows virion to be released from the cell
Also increases mobility of virion through mucus in the resp tract
What do Neuraminidase Inhibitors work against?
Influenza A and B
What are the ADRs of Neuraminidase inhibitors?
Nausea and vomiting
What are some examples of Neuraminidase Inhibitors?
Zanamavir
Oseltamivir
What is a major problem with regard to Amantandes and Neuraminidase Inhibitors?
Viruses developing Resistance to them
Name some DNA viruses
Herpes Simplex
Varicella Zoster
Epstein Barr Virus
