anatomy final (section 3) Flashcards
sensory afferent division
carries sensory signals from receptors to CNS1
Motor (efferent) division-
carries signals from CNS to glands and muscle cells to respond
Sympathetic division
arouse for action, accelerates heartbeat and respiration, inhibits digestive/urinary
parasympathetic division
calming, slow heartbeat and respiration, stimulates digestive and urinary
Afferent neurons
sensory detectors
interneurons
association- within CNS
- Carryout integrative functions
- Process, store, retrieve info
- Between sensory and motor
- 90% of neurons are interneurons
efferent neurons
motor- to effectors (muscles, glands)
Soma
control center- neurosome, cell body, perikaryon
- Single large nucleolus
- Cytoplasm- mitochondraia, lysosomes, golgi, inclusions, rough ER
- Neurofibrils- bundles of actin filaments
- No cell division
- Nissl bodies- dark staining of rough ER, protein synthesis
- Inclusions- glycogen granules, lipids, melanin, lipofuscin (golden brown pigment when lysosomes digest organelles), found more in old neurons
nissil bodies
dark staining of rough ER, protein synthesis
Inclusions
glycogen granules, lipids, melanin, lipofuscin (golden brown pigment when lysosomes digest organelles), found more in old neurons
- Terminal aborization
fine branches at distal end that include synaptic knob-terminal button that forms a synapse with next cell and synaptic vesicles which contain neurotransmitters
axon
- nerve fiber- originates from axon hillock- mound on soma, cylindrical, no branches until distal end
4 neuron types
multipolar, bipolar, unipolar, anaxonic
multipolar neuron
1 axon multiple dendrites, most common, in brain and spinal cord
bipolar neuron
1 axon and 1 dendrite eg olfactory, retina, inner ear
unipolar
single process leading away from soma eg sensory, skin, organs to spinal cord
anaxonic
many dendrites and no axon, eg visual
axonal transport and function
proteins made in the soma need to be transported
Functions: repair, be proteins in gated ion channels, enzymes, neurotransmitters
anterograde
move down an axon away from soma
retrograde
move up an axon towards soma
kinesin
motor protein in anterograde
dynein
motor protein in retrograde
fast anoxal transport
20-400 mm/day
- Anterograde fast transports organelles, enzymes, molecules
- Retrograde fast transports recycled materials or pathogens eg rabies, herpes, tetanus
slow axonal transport
- 5-10 mm/day, only atnerograde, moves enzymes, repairs cytoskeleton
* speed of repair and regeneration is governed by slow axonal transport
glial cells
support and protect neurons, bind neurons together, form framework
- Fetal- guides migrating neurons to destination
- Mature- if a mature neuron is not in contact with another neuron, it si covered by glial cell, prevents neurons from touching and allows for precise conductivity
oligodendrocytes
CNS; form myelin sheath in CNS, wraps around nerve fiber, insulates, conducts
ependymal
CNS; lines internal brain cavity and secretes cerebrospinal fluid
Microglia
CNS; small wandering macrophages from WBC, perform checkups on brains many times a day wander in search of cell debris to phagocytize
Astrocytes
CNS; most abundant glial cells in CNS, covers entire brain surface and nonsynaptic regions
• Supportive framework with perivascular feet with blood capillaries that form blood brain barrier
• Converts glucose to lactate to nourish neurons
• Secretes nerve growth factor which allows cells to grow and function
• Communicates electrically
• Absorbs excess neurotransmitters and ions
• Astrocytosis or astrosclerosis- form hardened scar tissue over damaged neuron
Schwann cells
PNS; form myelin sheath in PNS, covers neurons and assists in regenerations
Satellite cells
PNS; surround somas in ganglia, provide electrical insulation & regulates chemical environment
glioma
malignant tumors in brain, grow rapidly, chemo isn’t effective because of blood brain barrier, instead best treatment is surgery or radiation
myelination in PNS
Schwann cells wrap about 100 layers around nerve fiber; neurilemma-thick outermost coil that contains nucleus and cytoplasm, endoneurium- external to neurilemma and is fibrous connective tissue
**wraps in to out
myelination in CNS
oligodendrocytes myelinates several cells, anchored to multiple nerve fibers, cant migrate, push a new layer under the old myelin laer so that it spirals inward, no neurilemma or endoneurium
**wraps out to in
multiple sclerosis
myelin sheath deteriorates and is replaced with scar tissue, nerve conduction is disrupted, onset between 20-40 fatal within 25 years after diagnosed, cause may be autoimmune trigger by a virus, symptoms include double vision, tremors, numbness, and speech defects
Tay-Sachs
hereditary disorder of eastern European Jewish descent, abnormal accumulation of glycolipid GM2 which is normally composed of a lysosomal enzyme, the abnormal amount disrupts nerve conduction and leads to blindness, coordination loss and dementia
Mesaxon
neurilemma wrapping of an unmyelinated nerve
speed of nerve conduction depends on _______ and __________
diameter of nerve fiber and presence of myeline
fast conduction has (and example)
large diameter and myelin; skeletal muscle, vision, balance
slow conduction has (example)
small diameter and no myelin; stomach and pupil dilation
regeneration of peripheral nerves
cannot occur in CNS
• Can only occur if soma is intact and some neurilemma remains
• Fiber distal to injury degenerates, macrophages clean up debris
• Soma swells, endoplasmic reticulum breaks up, nucleus moves off center
• Axon stump sprouts growth, severed distal end still degenerates bc loss of NGF
• Schwann cells, basal lamina and nuerilemma form regeneration tube which guides the growing sprout to original target cell to reestablish synaptic contact
• Nucleus returns to normal shape and position
Nerve growth factor- NGF
protein secreted by gland/muscle/glial cells and picked up by axon terminals, prevents apoptosis, enables growing neurons to make contact with target cells
- Rita levi-Montalcini- 1950s, won noble prize in 1986 with Stanley Cohen for NGF research
3 factors the leads to resting membrane potential
- Ions diffuse down their concentration gradient
- Plasma membrane is selectively permeable
- Electrical attraction exists between cations and anions
in Na K pump, pumps out ____ for every ____ brings in
3Na, 2K
how are local potentials different from action potentials
locals are:
Graded- varies in magnitude
Decremented- weaker as it spreads farther away from origin
Reversible- K+ diffuse out to reestablish RMP
Excitatory or inhibitory- can hyperpolarize, become more negative than RMP
local potential
disturbances in membrane potential when neuron is stimulated,; response begins at dendrite and spreads to soma and then travels down axon to synaptic knobs
When stimulated-
- Open Na gates and Na rushes in
- Neutralizes the internal negative charge, DEPOLARIZATION, makes less negative
- Na diffuse for short distance inside producing a current to trigger zone= short range charge=LP
action potential
dramatic change in membrane voltage, generated when it hits trigger zone
- If excitatory local potential hits trigger zone and is strong enough, can generate action potential
- Spike- rapid rise in membrane potential, positive feedback
- Once passes 0 mV, Na becomes inactive and it peaks at +35 mV
- Positive inside and negative outside- depolarization
- At the peak, slow K gates are opened and K exits the cell to repolarize
- K gates stay open longer than Na gates do, Na and K switch places
- Is NONDEREMENTAL and IRREVERSIBLE
refractory period
no stimulation can cause and action potential; only occurs at some small areas of the membrane at a time, other parts can be stimulated but one may not be able to be
- Absolute- no chance of stimulation
- Relative- a very strong stimulation can cause action potential
Salutatory conduction
in myelinated fibers, nerve signals jump from node to node, fast conduction
4 categories fo NT
acetylcholine, amino acids, monoamines, neuropeptides
acetylcholine NT
in its own class, made of acetic acid and choline, muscle movement, mood, memory and learning possibly
amino acid NT
excitatory and inhibitory responses, eg glycine, glutamate, aspartate, gamma-aminobutyric acid (GABA)
monoamine NT
arousal, emotion and cognition, epinephrine, norepinephrine, dopamine, histamine, serotonin, made by removing –COOH from amino acid and keeping the –NH2
neuropeptides
long amino acid chains, feelings, hormones, modulators, has lasting effects, stored in secretory granules, eg substance P (pain), beta-endorphin