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Pharmacology > Autonomic Nervous system > Flashcards

Autonomic Nervous system Flashcards

1
Q

M1 receptor location

A

Sweat glands and the CNS

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2
Q

M1 receptor mechanism

A

Gq

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3
Q

Gq effects

A

activate PLC to produce IP3 and DAG. Increases calcium and activates protein kinases.

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4
Q

M2 receptor location

A

Heart, presynaptically.

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5
Q

M2 receptor mechanism

A

Gi

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6
Q

Gi effects

A

inhibits adenylyl cyclase, opens potassium channels and hyperpolarizes the cell.

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7
Q

M3 receptor locations

A

Ciliary muscle, iris circular muscle, endothelium, bronchioles, bladder, sphincters, GI.

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8
Q

M3 receptor mechanism

A

Gq

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9
Q

Nicotinic Nn receptor locations

A

postganglionic neurons and presynaptic terminals

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10
Q

Nicotinic Nm receptor locations

A

skeletal muscle

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11
Q

Nicotinic mechanism

A

Increases Na influx and depolarizes the cell

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12
Q

Alpha 1 receptor locations

A

Iris radial muscle, skin vessels, penis

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13
Q

Alpha 1 receptor mechanism

A

Gq

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14
Q

Alpha 2 receptor locations

A

GI smooth muslce, presynaptically

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15
Q

Beta 1 receptor locations

A

Heart, kidney.

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16
Q

Beta 1 receptor mechanism

A

Gs

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17
Q

Gs effects

A

Stimulates adenylyl cyclase causing depolarizaiton

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18
Q

Beta 2 receptor locations

A

Skeletal muscle vessels, bronchioles, bladder, liver

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19
Q

Beta 2 receptor mechanism

A

Gs

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20
Q

Beta 3 receptor locations

A

lipocytes

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21
Q

Beta 3 receptor mechanism

A

Gs

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22
Q

D1, D5 receptor locations

A

brain and renal vascular bed

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23
Q

D1, D5 receptor mechanism

A

Gs

24
Q

D2, D3, D4 receptor locations

A

brain and other tissues

25
Q

D2, D3, D4 receptor mechanism

A

Gi

26
Q

Alpha 1 on the iris

A

Contracts the radial muscle. Causes Mydriasis.

27
Q

M3 on the iris

A

Contracts the circular muscle. Causes Miosis.

28
Q

Beta on the lens

A

Relaxes ciliary muscle to accommodate far vision.

29
Q

M3 on the lens

A

Contracts the ciliary muscle to accommodate for near vision.

30
Q

M3 on intraocular pressure

A

Decreases IO pressure

31
Q

Alpha 1 on intraocular pressure

A

Decreases IO pressure

32
Q

Beta on intraocular pressure

A

Increases IO pressure

33
Q

Beta 1 on the heart

A

Increases HR and contractility

34
Q

M2 on the heart

A

Decreases HR ad contractility

35
Q

Alpha on blood vessels

A

vasoconstriction of skin and splanchnic vessels

36
Q

Beta 2 on blood vessels

A

vasodialtion of skeletal muscle vessels

37
Q

Beta 2 on bronchioles

A

bronchodilates

38
Q

M3 on bronchioles

A

bronchoconstricts

39
Q

alpha 2 on GI tract

A

Relaxes

40
Q

Beta 2 on GI tract

A

Relaxes

41
Q

M3 on GI tract

A

contracts

42
Q

alpha 1 on GI sphincters

A

contracts

43
Q

M3 on GI sphincters

A

relaxes

44
Q

M3 on gastric secretions

A

Increases

45
Q

Beta 2 on bladder

A

relaxes

46
Q

M3 on bladder

A

contracts

47
Q

Alpha 1 on bladder sphincter

A

contracts

48
Q

M3 on bladder sphincter

A

relaxes

49
Q

Beta 2 on uterus

A

relaxes

50
Q

Alpha on penis

A

Ejaculations

51
Q

M on penis

A

Erection

52
Q

M on eccrine glands

A

increases

53
Q

alpha on apocrine (stress) glands

A

increases

54
Q

Beta 3 on fat cells

A

lipolysis

55
Q

Beta 1 on kidneys

A

increased renin release

56
Q

Beta 2/alpha on liver

A

gluconeogenesis and glycogenolysis

Pharmacology (24 decks)

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