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Pharmacology > Anti coagulants > Flashcards

Anti coagulants Flashcards

1
Q

Heparin MOA

A

Acts as catalyst for antithrombin III

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2
Q

Heparin Indications

A

Prophylaxis for DVT and PE. Used in surgery and IV placement.

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3
Q

Heparin Pharmacokinetics

A

IV only with an immediate onset of action

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4
Q

Heparin Adverse effects

A

Hemorrhage (treat with protamine sulfate), Heparin induced thrombocytopenia.

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5
Q

Enoxaparin

A

LMW heparin

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6
Q

Fondaparinux

A

Synthetic pentasaccharide of heparin

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7
Q

LMW heparin pharmacokinetics

A

Injected Subcutaneously.

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8
Q

LMW heparin indications

A

Used in pregnancy. Lower incidence of HIT.

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9
Q

Lepirudin

A

Direct thrombin Inhibitor, IV only.

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10
Q

Lepirudin Indications

A

HIT alternative to heparin with Renal excretion (used in liver failure)

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11
Q

Argatroban

A

Direct thrombin inhibitor, IV only.

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12
Q

Argatroban Indications

A

HIT alternative to heparin with liver metabolism (used for renal failure)

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13
Q

Dabigatran

A

Direct thrombin inhibitor. Oral.

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14
Q

Rivaroxaban

A

Oral inhibitor of factor Xa

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15
Q

Apixaban

A

Oral inhibitor of factor Xa

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16
Q

Edoxaban

A

Oral inhibitor of factor Xa

17
Q

Warfarin MOA

A

Inhibits vitamin K epoxidase to stop the synthesis of coagulation factors II, VII, IX and X.

18
Q

Warfarin Adverse effects

A

Quickly reduces the levels of protein C so thrombosis can occur within the first few days. Co administer with heparin.

19
Q

Warfarin reversal

A

Vitamin K or fresh frozen plasma

20
Q

Warfarin contraindications

A

Pregnancy.

21
Q

Warfarin Drug interactions

A

Antibiotic absorption, estrogen, aspirin.

22
Q

Thrombolytic agents MOA

A

Converts plasminogen to plasmin with lyses thrombus from within.

23
Q

Thrombolytic agents indications

A

MI, PE, DVT

24
Q

Aminocaproic acid

A

Inhibits plasminogen activation. Used in bleeding disorders and reversal of fibrinolytic therapy.

25
Q

Transexamic acid

A

Inhibits plasminogen activation. Used in bleeding disorders and reversal of fibrinolytic therapy.

26
Q

Alteplase

A

Clot selective thrombolytic

27
Q

Reteplase

A

Clot selective thrombolytic

28
Q

Tenecteplase

A

Clot selective thrombolytic

29
Q

Aspirin MOA

A

Irreversibly inhibits COX for the lifetime of the platelet

30
Q

Aspirin indications

A

Secondary prevention of CV evens with established CV disease.

31
Q

Clopidigrel MOA

A

Irreversibly blocks the ADP receptor to inhibit platelet aggregation.

32
Q

Ticlopidine MOA

A

Irreversibly blocks the ADP receptor to inhibit platelet aggregation.

33
Q

DOC for thrombosis prevention in stent placement

A

Clopidigrel

34
Q

Abciximab

A

Inhibitor of GPIIb/IIIa receptor. IV only. Decreased platelet aggregation.

35
Q

Eptifibatide

A

Inhibitor of GPIIb/IIIa receptor. IV only. Decreased platelet aggregation.

36
Q

Tirofiban

A

Inhibitor of GPIIb/IIIa receptor. IV only. Decreased platelet aggregation.

Pharmacology (24 decks)

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