Teratogens

Question 1

ACEI

Answer 1

Renal damage

Question 2

Alkylating agents

Answer 2

Absence of digits, multiple anomalies

Question 3

Aminoglycosides

Answer 3

CN VIII toxicity

“A mean guy” hit the baby in the ear

Question 4

Carbamazepine

Answer 4

NTD, craniofacial defects, fingernail hypoplasia, developmental delay, IUGR

Question 5

Diethylstilbestrol (DES)

Answer 5

Vaginal clear cell adenocarcinoma, congenital Mullerian anomalies

Question 6

Folate antagonists

Answer 6

Neural tube defects

Question 7

Lithium

Answer 7

Ebstein anomaly (atrialized right ventricle)

Question 8

Methimazole

Answer 8

Aplasia cutis congenita

Question 9

Phenytoin

Answer 9

Fetal hydantoin syndrome = microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, intellectual disability

Question 10

Tetracyclines

Answer 10

Discolored teeth

“Teethracyclines”

Question 11

Thalidomide

Answer 11

Limb defects (phocomelia, micromelia - "flipper" limbs)
Limb defects with "tha-limb-domide"

Question 12

Valproate

Answer 12

Inhibition of maternal folate absorption = neural tube defects
Valpro”ate” inhibits fol”ate” absorption

Question 13

Warfarin

Answer 13

Bone deformities, fetal hemorrhage, abortion, ophthalmologic abnormalities
Do not wage “warfar”e on the baby; keep it “hep”py with “hep”arin (does not cross placenta)