Translocations Flashcards
1
Q
t(9;22)
A
Philadelphia chromosome CML Some ALL (adults, poor prognosis)
Tx = imatinib
2
Q
t(8;14)
A
Burkitt lymphoma
c-myc activation
Associated with EBV
3
Q
t(11;14)
A
Mantle cell lymphoma
Cyclin D1 activation (promotes G1 –> S)
4
Q
t(14;18)
A
Follicular lymphoma
Bcl-2 activation (stabilizes mitochondrial membrane so apoptosis cannot occur)
5
Q
t(15;17)
A
M3 type of AML
Acute promyelocytic Leukemia
Tx = all-trans retinoic acid (induces maturation of blasts)
6
Q
t(12;21)
A
B-ALL
Children
Good prognosis
