Oncogenes Flashcards
1
Q
Oncogenes
A
Gain of function = increased cancer risk
Need to damage only 1 allele
2
Q
BCR-ABL
A
CML, ALL
Tyrosine kinase
3
Q
Bcl-2
A
Follicular and undifferentiated lymphomas
Anti-apoptotic molecule (inhibits apoptosis)
4
Q
BRAF
A
Melanoma
Serine/threonine kinase
5
Q
c-kit
A
Gastrointestinal stromal tumor (GIST)
Cytokine receptor (for stem cell factor)
6
Q
c-myc
A
Burkitt lymphoma
Transcription factor
7
Q
HER2/neu (c-erbB2)
A
Breast, ovarian, gastric carcinomas
Tyrosine kinase
8
Q
L-myc
A
Lung tumor
Transcription factor
9
Q
N-myc
A
Neuroblastoma
Transcription factor
10
Q
RAS
A
Colon, lung, pancreatic cancers
GTPase
11
Q
RET
A
MEN 2A and 2B
Tyrosine kinase
