5. Anticoagulant and Inherited Bleeding Flashcards Preview

BDS2 BAMS Haematology > 5. Anticoagulant and Inherited Bleeding > Flashcards

Flashcards in 5. Anticoagulant and Inherited Bleeding Deck (35):
1

Contraindications of anticoagulant and inherited bleeding disorders (3)

Aspirin
NSAIDs
Antithrombotic medication (anticoagulants, antiplatelets)

2

Indications for oral anticoagulation (4)

AF
DVT
Heart valve disease/ mechanical heart valves
Thrombophilia

3

Types of oral anticoagulants (4)

Coumarins
Indanediones
Direct thrombin inhibitors
Factor Xa inhibitor

4

Types of wafarin drug interactions (2)

Potentiating drugs
Inhibiting drugs

5

Examples of warfarin potentiating drugs (4)

Amiodarone
Antibiotics
Alcohol (with liver disease)
NSAIDs

6

Examples of warfarin inhibiting drugs (4)

Carbamazepine, barbiturates
Cholesystramine
Griseofulvin
Alcohol (without liver disease)

7

Dangers of warfarin (overdose)

Haemorrhage

8

How do anti platelet drugs affect clotting (2)

Inhibiting platelet aggregation
Inhibiting thrombus formation in arterial circulation

9

Examples of anti platelet medications (8)

Low dose aspirin
Clopidogrel
Dipyridamole
Prasugrel and aspirin
Abciximab
Eptifibate and aspirin
Ticagrelor
Tirofaban

10

Definition of inherited bleeding disorder

Acquired defects which affect blood coagulation

11

What may inherited bleeding disorders affect (3)

Coagulation cascade
Platelet number
Platelet function
Combo

12

Types of rare bleeding disorders (2)

Inherited defects of other factors in coagulation pathway (not FVIII, IX, XI)
Inherited defect of platelet number/function

13

Types of haemophilia (3)

Haemophilia A
Haemophilia B
Haemophilia C

14

Genetics of haemophilia (2)

Sex-linked recessive inheritance
Males affected, females carriers

15

Definition of Haemophilia A

FVIII deficiency

16

Definition of Haemophilia B

FIX deficiency

17

Treatment of severe/moderate Haemophilia A

Use of recombinant factor VIII

18

Treatment of mild/carriers of Haemophilia A (2)

DDAVP
Very mid - oral tanexamic acid

19

Treatment of Haemophilia B (2)

No response to DDAVP
Prophylactic cover requires recombinant FIX

20

Definition of von Willebrand disease

Deficiency of von Willebrand factor

21

Genetics of von Willebrand disease (2)

Autosomal dominant
Both sexes equally affected

22

Types of von Willebrand disease (3)

Type 1 (dominant, mild)
Type 2 (dominant, mild)
Type 3 (recessive, severe)

23

Treatment of von WIllebrand disease (2)

Majority respond to DDAVP
Very mild cases - oral tranexamic acid

24

LA issues with inherited bleeding disorders (2)

IDB, lingual infiltration, post. sup. nerve block
Buccal infiltration, intra-ligamentary, intra-papillary safe

25

Definition of thrombophilia

Acquired condition superimposed on a genetic condition

26

Increased risk of what with thrombophilia

Clot development

27

Types of inherited bleeding syndromes (4)

Protein C deficiency
Protein S deficiency
Factor V leiden
Antithrombin III deficiency

28

How can acquired syndromes be obtained (7)

Antiphospholipid syndrome (lupus anticoagulants)
Oral contraceptives
Surgery
Trauma
Cancer
Pregnancy
Immobilisation

29

Types of platelet abnormalities (3)

Thrombocytopenia
Thrombocythaemia
Qualitative disorders (normal platelet number but abnormal function)

30

Definition of thrombocytopenia

Reduced platelet numbers

31

Definition of thrombocythaemia

Increased platelet numbers

32

Types of thrombocytopenia (3)

Idiopathic
Drug-related
Secondary to lymphoproliferative disorder

33

Types of inherited qualitative disorders (3)

Bernard Soulier syndrome
Hermansky Pudlak
Glanzmann's thromboasthenia

34

Types of acquired qualitative disorders (4)

Cirrhosis
Drugs
Alcohol
Cardiopulmonary bypass

35

Definition of Haemophilia C

Deficiency of FXI