6. Coagulation Tutorial Flashcards Preview

BDS2 BAMS Haematology > 6. Coagulation Tutorial > Flashcards

Flashcards in 6. Coagulation Tutorial Deck (16):
1

Stages of clotting (3)

(Bleeding)
Vasoconstiction
Platelet plug formation
Coagulation

2

Common inherited coagulopathies (3)

Haemophilia
Thombophilia (protein C deficiency, protein S deficiency, FV leiden, antithrombin III deficiency)
von Willebrand disease

3

Definition and function of antithrombin III

Glycoprotein (produced in the liver)
Inactivates several coagulation system pathways

4

Definition and function of Protein C

Vitamin-K dependent glycoprotein
Regulates anticoagulation, inflammation, cell death and maintains BV wall permeability
Deficiency can cause significantly increased thrombosis risk

5

Definition and function of Protein S

Vitamin-K dependent glycoprotein
Co-factor to protein C in the inactivation of FVa and FVIIIa

6

Description of platelet plug formation (2)

Platelets tick together to form a temporary seal to cover break in vessel wall
Activated by vWF in plasma

7

Description of coagulation

Reinforces platelet plug with insoluble fibrin (molecular glue)

8

What is DDAVP

Desmopressin

9

Uses of DDAVP (4)

Treat diabetes insidious
Treat haemophilia A
Treat von Willebrand disease
Treat high blood urea levels

10

DDAVP side effects (4)

Headaches
Diarrhoea
Low blood sodium
Release FVIII

11

Function of antifibrinolytic agents

Inhibit fibrinolysis by interfering with plasmin formation

12

Common reasons for thrombophilia (4)

Antithrombin III deficiency
Protein C deficiency
Protein S deficiency
Factor V leiden variant

13

Examples of FXa inhibitors (2)

Rivaroxiban
Apixiban

14

Example of direct thrombin inhibitor

Dabigatran

15

Blood tests used for bleeding (3)

Platelets
FBC
Bleeding time

16

Blood tests used for clotting (2)

INR
APPT