3 Anti-virals Flashcards

1
Q

What is the structure of viruses?

A

Nucleic acid with proteins (coat and enzymes).

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2
Q

What are the 8 steps of viral replication?

A

Virus attachment. Cell entry. Virus uncoating. Early protein production. Replication. Late protein production. Virus assembly. Virus release.

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3
Q

Which polymerases are unique among viruses?

A

RNA to RNA (RNA viruses)

RNA to DNA (Retroviruses and Hep B)

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4
Q

What are NRTI’s?

A

Nucleoside Reverse Transcriptase Inhibitor

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5
Q

NRTI’s are analogues. What are the thymidine analogues?

A

Zidovudine, azidothymidine.

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6
Q

Give two examples of non-nucleotide reverse transcriptase inhibitors.

A

Efavirenz

Nevirapine

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7
Q

Give two examples of protease inhibitors.

A

Atazanavir. Darunavir.

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8
Q

Give an example of a fusion inhibitor

A

Enfuviritide

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9
Q

Give an example of an integrase inhibitor

A

Raltegravir

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10
Q

Give an example of a chemokine receptor antagonist (CCR5).

A

Maraviroc

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11
Q

What is HAART?

A

2 NRTIs + NNRTI
2 NRTIs + boosted PI

Switch of CD4 replication.

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12
Q

Which HIV mutation confers resistance to Lamivudine?

A

M184V

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13
Q

Which gene confers resistance to HIV?

A

CCR 5 delta 32

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14
Q

What is Aciclovir and what is it used for?

A

Nucleoside analogue.

HSV. VZV.

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15
Q

What is Ganciclovir used for?

A

Cytomegalovirus

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16
Q

What is Ribavirin used for?

A

Hep C and RSV

17
Q

What are Interferons used for?

A

Hep C, Hep B

18
Q

Name a cytosine analogue (NRTI).

A

Lamivudine.

19
Q

Name two purine analogues (NRTIs).

A

Abacavir.

Tenofivir.

20
Q

Which other protease inhibitor is used to boost the doses of other PIs?

A

Ritonavir.