54. anti-coccidial

Question 1

Chemoprophylaxis drugs

Answer 1

Ionophore antibiotics
Triazines
Thers:
       -Amprolium
       - halofuginon
       - nicarbazin
       -robenidein

Question 2

Treatment

Answer 2

Sulphonamides

Triazines (toltrazuril)

Question 3

Ionophore antibiotics

Answer 3

Lipophilic
Penetrate inner and outer cell membranes:
-Not specific.. Highly toxic (cardia + respiratory)
- Never give to Eq, Ca, or Fe
- Interaction with Tiamulin, erythromycin,
sulfonamides, lincomycin
- lasalocid = has no toxic interactions: safe
Affects 1st schizonts gen
Monvalent
-Monensin, narasin, salinomycin
Divalent
- lasalocid
semidivalent
-Maduramicin

Question 4

Ionophore drugs

All chemoprophylaxix

Answer 4

Monesin
> Chemoprop turkey + chicken
Narasin 
> chicken
Salinomycin
> Chicken + rabbit
Lasalocid
> Chicken + turkey
Maduramicin
> Chicken + turkey
Semduramicin
> Chicken

Question 5

toxic interaction with Tiamulin

Answer 5

Monesin
Salinomycin
Narasin
meduramicin
semduramicin

Question 6

Triazuril

Answer 6

Tolrazuril: CPS + treatment
diclazuril: CPS

Question 7

Other Chemoprophylaxis:

Answer 7

Amprolium
 > Vit B1 antagonist (only for 14 days as can lead to beri beri disease)
> CPS, treatment and prevention
Halofuginan
> CPS
Robenidine
> Tastes meat
> used as CPS
Nicarbazin
> decrease tolerance heat stress (avoid summer application)

Question 8

Sulphonamides

Answer 8

PABA competitive antagonists –> Inhibit folic acid synth
2nd gen Schizonts: Allow development of natural immunity
Short term use only (Vit K def: heamorrhagic syndrome)
> Sulfachlorpyrazine
> Sulfadimetoxine
> sulfaquinoxaline
> Sulfadimidine
combine with Di-aminopyrimidines = potentiated