Antineoplastics- Antimetabolites

Question 1

Oral prodrug of 5-Fluorouracil catalyzed by thymidine phosphorylase

Answer 1

Capecitabine

Question 2

DOC for childhood ALL

Answer 2

6-mercaptopurine (6-MP)

Question 3

AE: Renal damage due to crystal deposits in tubules

Answer 3

Methotrexate

Question 4

Causes Hand/Foot Syndrome

Answer 4

5-Fluoruracil

Question 5

Prodrug that inhibits Ribonucleotide Reductase (RNR) and causes chain termination

Answer 5

Gemcitabine

Question 6

No drug interaction with Allopurinol

Answer 6

6-thioguanine (6-TG)

Question 7

Metabolized by Xanthine Oxidase and Thiopurine Methyltransferase

Answer 7

6-Mercaptopurine

Question 8

Not useful in patients with HGPRT deficiency (Lesch Nyhan Syndrome)

Answer 8

6-mercaptopurine

Question 9

Useful for colorectal cancer

Answer 9

Capecitabine and 5-Fluorouracil

Question 10

Useful for Pancreatic cancer

Answer 10

Gemcitabine

Question 11

Catabolized by Dihydropyrimidine dehydrogenase; deficiency causes Life-threatening diarrhea, myelosuppression, neurotoxicity

Answer 11

5-Fluorouracil

Question 12

Converted to polyglutamates to inhibit DHF Reductase

Answer 12

Methotrexate

Question 13

Used with Methotrexate to rescue THF to prevent bone marrow toxicity

Answer 13

Leucovorin (folinic acid)

Question 14

Combination therapy for colorectal cancer

Answer 14

5-Fluorouracil + Leucovorin

Question 15

First line treatment for metastatic colorectal cancer

Answer 15

Capecitabine

Question 16

AE: HUS and TTP

Answer 16

Gemcitabine

Question 17

Can be used topically for ketatoses and Basal Cell Carcinoma

Answer 17

5-Fluorouracil

Question 18

Antimetabolites are cell cycle specific for which phase?

Answer 18

S-phase

Question 19

Decreases intracellular GMP to inhibit DNA synthesis

Answer 19

6-thioguanine

Question 20

Hypoxanthine analog

Answer 20

6-mercaptopurine

Question 21

Converted TIMP to inhibit de novo purine synthesis

Answer 21

6-mercaptopurine

Question 22

Dose must be reduced if given with Allopurinol

Answer 22

6-mercaptopurine

Question 23

If deficient in Thiopurine Methyltransferase, which 2 drugs would require a lesser dose?

Answer 23

6-mercaptopurine and 6-thioguanine

Question 24

Neurotoxicity with Intrathecal administration

Answer 24

Methotrexate

Question 25

Competitively inhibits alpha and beta DNA Polymerase and inserts itself into nucleic acid

Answer 25

Cytarabine

Question 26

Only useful for hematologic malignancies; not useful against solid tumors

Answer 26

Cytarabine

Question 27

Folate Analog

Answer 27

Methotrexate

Question 28

Purine Analogs

Answer 28

6-Mercaptopurine and 6-Thioguanine

Question 29

Pyrimidine Analogs

Answer 29

5-Fluorouracil, Capecitabine, Deoxycytidine Analogs (Gemcitabine and Cytarabine)