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Pharmacology - Midterm 2 > Antineoplastics - Hormonal Agents, Signal Transduction Inhibitors, and Miscellaneous > Flashcards

Antineoplastics - Hormonal Agents, Signal Transduction Inhibitors, and Miscellaneous Flashcards

1
Q

glucocorticoid that induces lymphocyte apoptosis

A

Prednisone

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2
Q

MOA: bind to Estrogen receptors and act as agonists/antagonists depending on target tissue

A

Selective Estrogen Receptor Modulators (SERMS)

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3
Q

Pure Estrogen Receptor Antagonist with no agonist activity

A

Fulvestrant

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4
Q

Selective Estrogen Receptor Downregulator (SERD)

A

Fulvestrant

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5
Q

Agonist in non-breast tissues

A

Tamoxifen

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6
Q

Antiestrogen in the uterus and breast

A

Raloxifene

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7
Q

Antagonist in breast

A

Tamoxifen

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8
Q

Chemopreventive agent for women at risk of breast cancer

A

Tamoxifen

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9
Q

Prophylactic for breast cancer in high risk postmenopausal women

A

Raloxifene

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10
Q

agonist at bone to prevent postmenopausal Osteoporosis

A

Raloxifene

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11
Q

SERM that does not cause endometrial hyperplasia

A

Raloxifene

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12
Q

SERM that causes endometrial hyperplasia

A

Tamoxifen

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13
Q

increases ER degradation, reducing number in cells

A

Fulvestrant

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14
Q

used in Tamoxifen-resistant breast cancer

A

Fulvestrant

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15
Q

inhibit Aromatase to prevent Estrone synthesis from Androstenedione

A

Aromatase inhibitors

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16
Q

Non-steroidal Aromatase inhibitors

A

Anastrozole and Letrozole

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17
Q

Steroidal Aromatase Inhibitor

A

Exemestane

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18
Q

Irreversible inhibitor of Aromatase

A

Exemestane

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19
Q

Competitive reversible inhibitors of Aromatase

A

Anastrozole and Letrozole

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20
Q

Androgen Receptor Blocker

A

Flutamide

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21
Q

GnRH analogs

A

Goserelin and Leuprolide

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22
Q

MOA of Flutamide

A

non-steroidal, competitive antagonist of androgen receptor

23
Q

indications for Flutamide

A

Prostatic Carcinoma

24
Q

Indications for GnRH analogs

A

Prostatic Carcinoma

25
Q

stimulate release of FSH and LH from ant. pit

A

GnRH analogs

26
Q

AE: mild gynecomastia and reversible hepatotoxicity

A

Flutamide

27
Q

Biphasic response (initial phase/flare and delayed phase)

A

GnRH analogs

28
Q

Concurrent administration with Flutamide counteracts effects

A

GnRH analogs

29
Q

inhibits EGFR Tyrosine Kinase; for NSCLC

A

Gefitinib

30
Q

inhibits EGFR Tyrosine Kinase for colorectal cancer expressing KRAS wild type

A

Cetuximab

31
Q

EGFR Tyrosine Kinase inhibitor for pancreatic cancer and NSCLC

A

Erlotinib

32
Q

inhibits EGFR and ErbB2

A

Lapatinib

33
Q

Humanized monoclonal ab against ErbB2 (HER2)

A

Trastuzumab

34
Q

Used in breast cancer with HER2 over expression but causes cardiotoxicity

A

Trastuzumab

35
Q

used for NSCLC and Pancreatic Cancer; inhibits EGFR and ErbB2

A

Lapatinib

36
Q

inhibits Bcr-Abl in CML

A

Imatinib

37
Q

inhibits c-kit –> used for GIST

A

Imatinib

38
Q

Idiopathic Hypereosinophilic Syndrome

A

Imatinib

39
Q

Inhibits RAF Serine/Threonine Kinase

A

Sorafenib

40
Q

Used against Renal Cell Carcinoma

A

Sorafenib

41
Q

Inhibits VEGF-R2, VEGF-R3, and PDGFR-beta

A

Sorafenib

42
Q

Proteasome inhibitor that inhibits growth and induces apoptosis

A

Bortezomib

43
Q

Used for Mantle Cell Lymphoma

A

Bortezomib

44
Q

Inhibits Angiogenesis and VEGFR-1, 2, and PDGFR

A

Sunitinib

45
Q

Used for Renal Cell Carcinoma and GIST

A

Sunitinib

46
Q

Used against ALL due to tumor cells lacking exogenous source of L-Asparagine (normal cells have Asparagine Synthase)

A

Asparaginase

47
Q

AE of Asparaginase

A

pancreatitis, decreased clotting factors, seizures and coma, hypersensitivity

48
Q

Kills cells in S phase and inhibits Ribonucleotide Reductase, inhibiting DNA Synthesis

A

Hydroxurea

49
Q

used for Sickle Cell Anemia and Malignant Melanoma

A

Hydroxyurea

50
Q

AE of Hydroxyurea

A

Skin hyperpigmentation, macrocytosis, myelosuppression

51
Q

MOA: stimulates NK cells to kill transformed cells by increasing HLA expression on tumor cells

A

Interferon alpha

52
Q

AE of Interferon alpha

A

flu-like symptoms

53
Q

Indications of Interferon alpha

A

Kaposi Sarcoma, Hairy Cell Leukemia, Renal Cell Carcinoma, HPV, HBV, and HCV

Pharmacology - Midterm 2 (16 decks)

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