Antineoplastics - Microtubule Inhibitors

Question 1

Which phase of the cell cycle is inhibited in Microtubule Inhibitors?

Answer 1

M phase

Question 2

MOA of Vinblastine and Vincristine

Answer 2

Vinca Alkaloids; Bind beta tubulin to prevent microtubule formation, arresting cells in M phase

Question 3

MOA of Paclitaxel and Docetaxel

Answer 3

Taxanes; Bind beta tubulin at different site than Vinca Alkaloids to promote microtubule polymerization but inhibit depolymerization ==> activates apoptosis

Question 4

MOA of Etoposide and Teniposide

Answer 4

Inhibit Topoisomerase II at late S phase and early G2

Question 5

Topoisomerase I inhibitors, cutting 1 strand of DNA

Answer 5

Topotecan and Irinotecan

Question 6

Bone marrow sparing but causes peripheral neuropathy

Answer 6

Vincristine

Question 7

Vinca Alkaloid, potent vesicant

Answer 7

Vinblastine

Question 8

Epipodophyllotoxin indicated for refractory childhood ALL

Answer 8

Teniposide

Question 9

Vinca Alkaloid that causes bone marrow suppression (dose-limiting effect)

Answer 9

Vinblastine

Question 10

Indications for Vincristine

Answer 10

hematologic malignancies and pediatric tumors

Question 11

AE: neurotoxicity with peripheral neuropathy, Paralytic Ileus, Optic Atrophy, SIADH

Answer 11

Vincristine

Question 12

fecal excretion via hepatobiliary route

Answer 12

Taxanes; dose reduction in hepatic dysfxn

Question 13

Camptothecins

Answer 13

Topoisomerase I Inhibitors: Topotecan, Irinotecan

Question 14

Microtubule Inhibitors

Answer 14

Vinca Alkaloids and Taxanes

Question 15

Taxanes

Answer 15

Paclitaxel, Docetaxel

Question 16

Epipodophyllotoxins

Answer 16

Etoposide, Teniposide

Question 17

2nd line therapy for advanced Ovarian Cancer and SCLC

Answer 17

Topotecan

Question 18

combined with 5-Fluorouracil and Leucovorin to treat metastatic colorectal cancer

Answer 18

Irinotecan

Question 19

Albumin-bound form of Paclitaxel that does not cause hypersensitivity

Answer 19

Abraxane

Question 20

Used as pretreatment for Paclitaxel

Answer 20

Dexamethasone, Diphenyhydramine, and H2 blocker

Question 21

2nd line therapy in advanced breast cancer and NSCLC

Answer 21

Docetaxel

Question 22

Used as pretreatment for Docetaxel to prevent fluid retention

Answer 22

Dexamethasone

Question 23

Taxane that causes hypersensitivity and peripheral neuropathy

Answer 23

Paclitaxel

Question 24

Epipodophyllotoxin indicated for testicular cancer and SCLC

Answer 24

Etoposide