Antineoplastics - Antitumor Antibiotics

Question 1

contains DNA binding region and iron-binding region; causes ROS formation and DNA strand breakage

Answer 1

Bleomycin, cell cycle specific

Question 2

Causes pulmonary fibrosis due to low hydrolase activity

Answer 2

Bleomycin

Question 3

DNA intercalation, Topoisomerase II inhibitor, alters membrane fluidity and ion transport, generates ROS through an iron-dependent enzyme mediated reduction

Answer 3

Anthracyclines

Question 4

Cardiotoxicity: dilated cardiomyopathy associated with HF

Answer 4

Anthracyclines

Question 5

Anthracycline used for AML but not solid tumors

Answer 5

Daunorubicin

Question 6

Radiation Recall Rxn

Answer 6

Anthracyclines

Question 7

iron-chelating agent given to reduce cardiotoxicity

Answer 7

Dexrazoxane

Question 8

Antitumor antibiotic that causes flagellated skin hyperpigmentation

Answer 8

Bleomycin

Question 9

Anthracycline with broad spectrum of activity

Answer 9

Doxorubicin

Question 10

limited bone marrow suppression

Answer 10

Bleomycin

Question 11

cell cycle non-specific antitumor antibiotics

Answer 11

Anthracyclines

Question 12

causes pneumonitis and pulmonary fibrosis

Answer 12

Bleomycin