Reproduction Final Part 2 (Pozor) Flashcards

1
Q

On what cells are FSH receptors found? One what cells are LH receptors found?

A

FSH receptors –> granulosa cells

LH receptors –> thecal cells (later on granulosa cells too)

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2
Q

What effects do low levels of estrogen have on GnRH, FSH, and LH? What about high levels?

A
Low Estrogen (-)--> GnRH, FSH, LH
High Estrogen (+)--> GnRH (+)--> FSH and LH
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3
Q

Contrast monoestrus, polyestrus, and seasonally polyestrus.

A

Monoestrus –> estrus occurs once a year (wolves, foxes, bears, and dogs)
Polyestrus –> estrus occurs multiple times a year (cattle, swine, and rodents)
Seasonally polyestrus –> estrus occurs multiple times during specific seasons only (horses, sheep, and goats)

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4
Q

Contrast long-day breeders and short-day breeders.

A

Long-day breeders like little darkness. Therefore:
Long days –> Little darkness –> Little melatonin –> Estrus
Example: horses

Short-day breeders like ample darkness. Therefore:
Short days –> Ample darkness –> Ample melatonin —> Estrus
Example: sheep, goats

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5
Q

What hormone dominates the follicular phase? From where is this hormone secreted? What proportion of the estrous cycle does this comprise?

A

Estrogen
from the growing Ovarian Follicle
~20%

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6
Q

What hormone dominates the luteal phase? From where is this hormone secreted? What proportion of the estrous cycle does this comprise?

A

Progesterone
from the Corpus Luteum
~80%

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7
Q

Describe the four stages of the estrous cycle.

A

Proestrus –> High progesterone; follicles are recruited for ovulation and female tract is preparing for mating; estrogen begins to increase

Estrus –> High estrogen; mating; ovulation occurs (except for cow who ovulates at the end of estrus)

Metestrus –> Low progesterone and estrogen; formation of a functional corpus luteum; progesterone begins to increase

Diestrus –> Max progesterone; if pregnancy doesn’t occur, PGF2alpha initiates luteolysis

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8
Q

T/F: High levels of progesterone inhibit GnRH secretions.

A

TRUE

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9
Q

Name a hormone that inhibits FSH besides estrogen.

A

Inhibin

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10
Q

Describe lutenizing hormone (LH).

A
  • Causes follicular maturation and ovulation
  • Promotes development and maintenance of corpus luteum
  • Inhibited by high levels of progesterone
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11
Q

Describe estrogen.

A
  • Produced by growing dominant follicle
  • Peaks around ovulation
  • Responsible for sexual receptivity
  • Where low levels of estrogen are inhibitory on GnRH, high levels are stimulatory, which lead to the LH surge
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12
Q

Describe progesterone.

A
  • Produced by the corpus luteum
  • Dominant hormone during diestrus
  • Essential for pregnancy maintenance
  • Inhibits estrus behavior
  • Inhibits GnRH and LH
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13
Q

Name the enzyme that degrades and weakens the follicular wall, which leads to ovulation.

A

Collagenase

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14
Q

Which cells produce testosterone for male development? Which produce Mullerian Inhibiting Hormone?

A

Leydig –> Testosterone

Sertoli –> MIH

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15
Q

What cells prevent sperm from entering blood by creating the blood-testis barrier?

A

Sertoli cells

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16
Q

T/F: Spermatocytes are immunogenic.

A

TRUE

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17
Q

Where in the embryonic gonad of the male are the sex cords located?

A

In the Medulla

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18
Q

Where in the embryonic gonad of the female are the germ cells located?

A

In the Cortex

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19
Q

T/F: Sertoli cells divide throughout sexual maturity of a male.

A

FALSE

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20
Q

Define: Spermatocytogenesis

A

Mitotic divisions involving proliferation and maintenance of spermatogonia.

21
Q

Define: Spermiogenesis

A

Morphologic transformation of spherical spermatids into spermatozoa.

22
Q

Contrast Type A spermatogonia and Type B spermatogonia.

A

Type A serve as the replaceable stem cell population and are found residing on Sertoli cells.
Type B serve as those that will undergo further development into spermatids in the lumen.

23
Q

Describe the 4 phases of meiosis I in spermatogenesis.

A
  • Leptotene –> DNA synthesis
  • Zygotene –> Pairing of sister chromatids
  • Pachytene –> Exchange of genetic material
  • Diplotene –> Separation of sister chromatids
24
Q

At what point are spermatogonia referred to as spermatocytes?

A

After initiation of meiosis I.

25
Q

At what point are primary spermatocytes referred to as secondary spermatocytes?

A

After completion of prophase I.

26
Q

Name some changes that occur during spermiogenesis.

A
  • Nuclear DNA is condensed with protamines (testis-specific histones)
  • Axoneme, tail, and acrosome are formed
  • Number of mitochondria decreases
  • Excess cytoplasm is “pinched off”
27
Q

At what point are secondary spermatocytes referred to as spermatids?

A

After the second division, resulting in haploid cells

28
Q

The A2 type of spermatogonia undergo mitosis to form types A3 through B2. This is controlled by what hormone?

A

FSH

29
Q

Spermiogenesis is controlled by what two hormones?

A

LH and Testosterone

30
Q

Define: Spermatogenic cycle

A

A complete series of stages in one seminiferous tubule.

31
Q

Define: Spermatogenic wave

A

The distribution of the stages along the length of the tubule in the wave, if the whole length of the seminiferous tubule is viewed at any given time.

32
Q

Name some considerations the female reproductive tract must ensure for successful semen deposition.

A
  • Spermatozoa capable of fertilization are transported to the oviductal ampulla.
  • Spermatozoa which are not yet capable of fertilization can be safely stored in the tract
  • Spermatozoa which are incapable of fertilization (or dead) are removed from the tract.
33
Q

Name some different elements of spermatozoa transport.

A
  • Sperm motility
  • Uterine motility
  • Oviductal motility
  • Ciliar activity
34
Q

In what species is intravaginal deposition of semen of relevance?

A
  • Human
  • Bovine
  • Ovine
  • Caprine
  • Feline
35
Q

In what species is intrauterine deposition of semen of relevance?

A
  • Equine
  • Porcine
  • Canine
  • Llama-ine
36
Q

Binding of spermatozoa to the oviductal epithelial cells (increases/decreases) their viability.

A

Binding of spermatozoa to the oviductal epithelial cells INCREASES their viability.

37
Q

During storage, what prevents spermatozoa from undergoing capacitation?

A

Intracellular calcium concentrations

38
Q

Name some physical barriers spermatozoa must overcome.

A
  • Cervix
  • Length of the uterus
  • Utero-tubal junction (UTJ)
39
Q

Increased uterine contractility occurs as a result of what?

A

Oxytocin release during mating

40
Q

Since the cervix is relaxed during estrus, the (ascending/descending) contractions result in a great (help/loss) of spermatozoa.

A

Since the cervix is relaxed during estrus, the DESCENDING contractions result in a great LOSS of spermatozoa.

41
Q

Spermatozoa are inflammatory. What immunological agent arrives as a result?

A

Polymorphonuclear neutrophils (PMNs)

42
Q

Excess spermatozoa in the oviduct are not eliminated by inflammation. How are they eliminated?

A

They are phagocytosed by epithelial cells.

43
Q

When do most species ovulate an ovum? Name an exception.

A

Most ovulate during metaphase II.

Dogs ovulate during 1st meiotic division

44
Q

At ovulation, what three things is the oocyte surrounded by and what is their purpose?

A
  • Vitteline membrane –> serves as a plasma membrane
  • Zona pellucida –> made of glycoproteins; provides high degree of specificity
  • Cumulus oophorus –> made of loosely-packed granulosa cells
45
Q

T/F: Spermatozoa are capable of fertilization after exiting the seminiferous tubules.

A

FALSE

Spermatozoa are capable of fertilization after exiting the epididymus, where they underwent maturation.

46
Q

What is the site of fertilization?

A

Ampulla of the oviduct

47
Q

What is the primary sperm mover in the uterus?

A

Uterine contractile activity

48
Q

In most domestic species, motility is eliminated completely upon arrival at the _______________, which acts as a “storage site” for sperm cells.

A

In most domestic species, motility is eliminated completely upon arrival at the ISTHMUS OF THE OVIDUCT , which acts as a “storage site” for sperm cells.