SALBUTAMOL

Question 1

Drug class

Answer 1

beta-2 agonist

Question 2

How does it work? (3)

Answer 2

1. beta-2 receptors are found in the smooth muscle of the bronchi, GI tract, uterus and blood vessels
2. G proteins are stimulated which leads to smooth muscle relaxation
3. it is short acting

Question 3

Indications

Answer 3

1. asthma
2. copd
3. hyperkaelemia

Question 4

How does salbutamol work in hyperkaelemia? (2)

Answer 4

1. stimulates Na/K ATPase pump

2. shifts K+ from extra cellar to intracellular component

Question 5

Contra-indications

Answer 5

1. CVD - cause angina or arrhythmias

Question 6

Side effects (4)

Answer 6

1. tachycardia
2. palpitations
3. anxiety
4. tremor

Question 7

Interactions (3)

Answer 7

1. beta-blockers - reduces effectiveness
2. theophyllline - hyopkaelemia - monitor
3. corticosteroids - hypokaelmia - monitor

Question 8

Elimination

Answer 8

urine