CIPROFLOXACIN

Question 1

Drug class

Answer 1

quinolones

Question 2

How does to work? (3)

Answer 2

• inhibit DNA synthesis
• aerobic gram negative bacteria
• urinary and GI infections

Question 3

What is the problem with quinolones?

Answer 3

bacteria quickly develop resistance to them

Question 4

Indications (3)

Answer 4

1. UTI
2. severe GI infections
3. Newer ones - LRTI e.g. Pseudomonas aeruginosa

Question 5

Contraindications (3)

Answer 5

1. seizures
2. growing people - arthropathy
3. QT prolongation

Question 6

Side effects (6)

Answer 6

1. GI upset
2. hypersensitivity
3. neurological effects

• seizures
• hallucinations

4. rupture of muscle tendons
5. arrhythmias
6. c.difficile

Question 7

Interactions (5)

Answer 7

1. cytochrome P450 enzyme inhibition
2. theophylline
3. NSAIDS - seizures
4. prednisolone - tendon rupture
5. drugs that prolong QT interval

Question 8

What are examples of drugs that prolong QT interval? (5)

Answer 8

1. amiodarone
2. antipsychotics
3. quinine
4. macrolide antibiotics
5. SSRIs

Question 9

Elimination

Answer 9

urine