TISSUE PLASMINOGEN ACTIVATORS

Question 1

Drug class

Answer 1

thrombolytics

Question 2

How does it work? (4)

Answer 2

1. dissolves blood by activating plasminogen
2. this forms plasmin
3. plasmin is an enzyme which is capable of breaking cross links between fibrin molecules
4. fibrin molecules are responsible for providing the structural integrity of the clot

Question 3

Indications (3)

Answer 3

1. heart
   - acute MI
2. lungs
   - PE
3. brain
   - acute ischaemic stroke

Question 4

Contra-indications (4)

Answer 4

1. stroke

• acute
• severe
• diabetics
• convulsions

2. hypersensitivity
   - gentamicin
3. blood glucose
   - hyper/hypo
4. liver
   - hepatic

Question 5

Side effects (4)

Answer 5

1. GI

• nausea
• vomitting
• dark urine
• dark stools
• difficulty swallowing

2. bleeding
3. dizzy
4. lungs
   - difficulty breathing

Question 6

Interactions (3)

Answer 6

1. fibrinogen alpha chain

• a protein in humans that encodes fibrinogen
  2. LRP1
• key in signalling of proteins
  3. SERPIN1
• involved in protease inactivity

Question 7

Elimination

Answer 7

1. hepatic metabolism