FLUDROCORTISONE Flashcards
1
Q
Drug class
A
mineralocorticoids
2
Q
What does it do? (3)
A
- replaces aldosterone in adrenal insufficiency
- Addison’s - increases sodium levels
- increased blood vol
3
Q
How does it work? (3)
A
- binds to mineralocorticoid receptor (aldosterone receptor)
- this causes an increase in ion and water transport
- this raises extracellular fluid and bp
4
Q
Indications
A
Addison’s disease
5
Q
Contra-indications (8)
A
- allergic
- systemic fungal infection
- live virus vaccination e.g. smallpox
- pregnancy
- underactive thyroid
- kidney and liver problems
- recent TB
- eye infection
- measles
- chicken pox
- herpes
6
Q
Side effects (5)
A
- GI
- upset
- vomitting
- indigestion
- increased appetite
- head
- dizzy
- lightheadedness
- headache
- mood
- nervousness - sleep difficulty
- increased sweating
7
Q
Interactions (4) - 3am
A
- anabolic steroids
- methotrexate
- anticoagulants
- amphoetericin B
8
Q
Elimination (2)
A
- urine mainly
2. faeces and bile
