THYROXINE Flashcards
1
Q
Drug class (3)
A
- thyroid hormone
- levothyroxine
- liothyronine
2
Q
How does it work? (3)
A
- T4 = Levothyroxine
- converted into T3 (active form) triodothyronine
- regulate metabolism and growth
3
Q
Indications
A
hypothyroidism
4
Q
Contraindications (2)
A
- heart
- cardiac ischaemia
- coronary artery disease
- hypopituitarism
- must give cortisol to prevent Addison’s disease
5
Q
Side effects (4)
A
- too much
- hyperthyroidism - GI
- vomitting
- diarrhoea
- weight loss
- Cardiac
- palpitations
- angina
- arrhythmias
- neurological
- tremors
- restlessness
- insomnia
6
Q
Interactions (4)
A
- antacids, iron, calcium and salt
- reduce absorption
- admin 4 hrs gap
- cytochrome P450 inducers
- increase levothyroxine
e. g. phenytoin - diabetics
- increases insulin requirements - warfarin
- enhances it’s effects
7
Q
Elimination
A
urine
