6/12/2023

Question 1

Platinol

Answer 1

Cisplatin

Question 2

Cisplatin MOA

Answer 2

Inhibits DNA synthesis by formation of DNA cross-links; denatures the double helix; covalently binds to DNA bases and disrupts DNA function.

Question 3

Cisplatin class

Answer 3

Antineoplastic alkylating agent

Question 4

Citalopram MOA

Answer 4

Selectively inhibits serotonin reuptake in the presynaptic neurons and has minimal effects on norepinephrine and dopamine.

Question 5

Citalopram class

Answer 5

SSRI

Question 6

Leustatin

Answer 6

Cladribine

Question 7

Cladribine MOA

Answer 7

Purine nucleoside analogue; gets phosphorylated, incorporates into DNA, resulting in the breakage of DNA strand to stop DNA synthesis and repair. Cell cycle non-specific.

Question 8

Cladribine class

Answer 8

Antimetabolite (antineoplastic)

Question 9

Biaxin

Answer 9

Clarithromycin

Question 10

Clarithromycin MOA

Answer 10

Binds to the 50S ribosomal subunit resulting in inhibition of protein synthesis.

Question 11

Clarithromycin class

Answer 11

Macrolide antibiotic

Question 12

Cleocin

Answer 12

Clindamycin

Question 13

Clindamycin class

Answer 13

Lincosamide antibiotic

Question 14

Clindamycin MOA

Answer 14

Reversibly binds to the 50S ribosomal subunit, preventing peptide bond formation and inhibiting bacterial proteins synthesis

Question 15

Onfi

Answer 15

Clobazam

Question 16

Clobazam MOA

Answer 16

Long-acting benzodiazepine. Binds to benzodiazepine receptors on the postsynaptic GABA neuron, enhancing the inhibitory effect of GABA on neuronal excitability, resulting in increased neuronal membrane permeability to chloride ions.

Question 17

Clobazam class

Answer 17

Benzodiazepine

Question 18

Catapres

Answer 18

Clonidine

Question 19

Clonidine class

Answer 19

alpha-2 adrenergic agonist

Question 20

Clonidine MOA

Answer 20

Stimulates alpha-2 adrenergic receptors in the brain stem, activating an inhibitory neuron, resulting in reduced sympathetic outflow from the CNS, producing a decrease in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.

For ADHD, mechanism is unknown; it may regulate subcortical activity in the prefrontal cortex, the area of the brain responsible for emotions, attention, and behaviors, causing less hyperactivity, impulsiveness, and distractibility.

Question 21

Codeine class

Answer 21

Opioid analgesic

Question 22

Codeine MOA

Answer 22

binds to opioid receptors in the CNS, causing inhibition of ascending pain pathways, altering the perception of and response to pain.

Question 23

Cytoxan

Answer 23

Cyclophosphamide

Question 24

Cyclophosphamide MOA

Answer 24

Alkylating agent; prevents cell division by cross-linking DNA strands and decreasing DNA synthesis. Cell cycle non-specific.

Question 25

Cyclophosphamide class

Answer 25

Alkylating agent (antineoplastic)

Question 26

Sandimmune

Answer 26

Cyclosporine

Question 27

Cyclosporine MOA

Answer 27

Inhibition of production and release of IL-2 and inhibits IL-2-induced activation of resting T-cells

Question 28

Cyclosporine class

Answer 28

Calcineurin inhibitor

Question 29

Ara-C

Answer 29

Cytarabine

Question 30

Cytarabine MOA

Answer 30

Pyrimidine analog, which gets incorporated into DNA. Primary action is inhibition of DNA polymerase, resulting in decreased DNA synthesis and repair. Specific for S phase of the cell cycle.

Question 31

Cytarabine class

Answer 31

Pyrimidine analog antimetabolite (antineoplastic)

Question 32

Dalvance

Answer 32

Dalbavancin

Question 33

Dalbavancin MOA

Answer 33

Lipoglycopeptide which binds to the D-alanyl-D-alanine terminus of peptidoglycan, preventing cross-linking and interfering with cell wall synthesis.

Question 34

Dalbavancin class

Answer 34

Lipoglycopeptide

Question 35

Farxiga

Answer 35

Dapagliflozin

Question 36

Dapagliflozin MOA

Answer 36

Inhibits sodium-glucose cotransporter 2 (SGLT2) in the proximal renal tubules, reducing reabsorption of filtered glucose from the tubular lumen and lowers the renal threshold for glucose. This results in increased renal excretion of glucose, thereby reducing plasma glucose concentrations. Also reduces sodium reabsorption, which may decrease cardiac preload/afterload, downregulate sympathetic activity, and decrease intraglomerular pressure.

Question 37

Dapagliflozin class

Answer 37

SGLT2 inhibitor

Question 38

Cubicin

Answer 38

Daptomycin

Question 39

Daptomycin MOA

Answer 39

Binds to components of the cell membrane of susceptible organisms and causes rapid depolarization, inhibiting intracellular synthesis of DNA, RNA, and protein.

Question 40

Daptomycin class

Answer 40

cyclic lipopeptide

Question 41

Darzalex

Answer 41

Daratumumab

Question 42

Daratumumab class

Answer 42

anti-CD38 monoclonal antibody (antineoplastic)

Question 43

Daratumumab MOA

Answer 43

Antibody directed against CD38. CD38 is a cell surface glycoprotein which is highly expressed in myeloma cells, but expressed at low levels on normal lymphoid and myeloid cells.

Question 44

Aranesp

Answer 44

Darbepoetin

Question 45

Darbepoetin MOA

Answer 45

Induces erythropoiesis by stimulating the division and differentiation of committed erythroid progenitor cells; induces release of reticulocytes from the bone marrow into the bloodstream, where they mature into erythrocytes.

Question 46

Darbepoetin class

Answer 46

Colony stimulating factor; erythropoiesis-stimulating agent (ESA)

Question 47

Cerubidine

Answer 47

Daunorubicin

Question 48

Daunorubicin MOA

Answer 48

Inhibits DNA and RNA synthesis by intercalation between DNA base pairs by steric obstruction. Also inhibits DNA repair by inhibiting topoisomerase II.

Question 49

Daunorubicin class

Answer 49

Anthracycline; topoisomerase inhibitor (antineoplastic)

Question 50

Vyxeos

Answer 50

Daunorubicin liposomal/cytarabine liposomal

Question 51

Daunorubicin/cytarabine liposomal MOA

Answer 51

Daunorubicin inhibits DNA and RNA synthesis by intercalating between DNA base pairs and causes steric obstruction. It also inhibits topoisomerase II. Cytarabine is a pyrimidine analog, which gets incorporated into DNA and inhibits DNA polymerase, causing decreased DNA synthesis and repair.

Question 52

Firmagon

Answer 52

Degarelix

Question 53

Degarelix MOA

Answer 53

Gonadotropin-releasing hormone (GnRH) antagonist which reversibly binds to GnRH receptors in the anterior pituitary gland, blocking the receptor and decreasing the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH), resulting in rapid androgen deprivation by decreasing testosterone production.

Question 54

Degarelix class

Answer 54

Gonadotropin-releasing hormone antagonist (antineoplastic)

Question 55

Prolia

Answer 55

Denosumab

Question 56

Xgeva

Answer 56

Denosumab

Question 57

Denosumab class

Answer 57

Bone-modifying agent

Question 58

Denosumab MOA

Answer 58

Monoclonal antibody with affinity for nuclear factor-kappa ligand (RANKL). Denosumab binds to RANKL, blocks the interaction between RANKL and RANK, and prevents osteoclast formation, leading to decreased bone resorption and increased bone mass in osteoporosis. In solid tumors with bony metastases, denosumab decreases osteoclastic activity, leading to decreased skeletal-related events and tumor-induced bone destruction.