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Top 300 Drugs > 6/13/2023 > Flashcards

6/13/2023 Flashcards

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1
Q

Dexamethasone MOA

A

Long-acting corticosteroid with minimal sodium-retaining potential. It decreases inflammation by suppression of neutrophil migration, decreased production of inflammatory mediators, and reversal of increased capillary permeability; suppresses normal immune response.

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2
Q

Dexamethasone class

A

corticosteroid

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3
Q

Valium

A

Diazepam

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4
Q

Dicyclomine MOA

A

Blocks the action of acetylcholine at parasympathetic sites in smooth muscle, secretory glands, and CNS

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5
Q

Dicyclomine class

A

Anticholinergic agent

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6
Q

Diphenoxylate/atropine MOA

A

Diphenoxylate - inhibits excessive GI motility and GI propulsion

Atropine - a subtherapeutic amount is used to discourage abuse

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7
Q

Diphenoxylate/atropine class

A

Antidiarrheal

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8
Q

Depakote

A

Divalproex

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9
Q

Divalproex MOA

A

Causes increased availability of GABA to neurons, or may enhance the action of GABA or mimic its action at postsynaptic receptor sites. Also blocks voltage-dependent sodium channels, which results in suppression of high-frequency repetitive neuronal firing.

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10
Q

Divalproex class

A

Antiseizure agent, antimanic agent

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11
Q

Taxotere

A

Docetaxel

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12
Q

Docetaxel MOA

A

Promotes the assembly of microtubules from tubulin dimers, and inhibits the depolymerization of tubulin which stabilizes the microtubules in the cell. Results in inhibition of DNA, RNA, and protein synthesis. Most activity occurs during M phase of the cell cycle.

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13
Q

Docetaxel class

A

Antimicrotubular, taxane (antineoplastic)

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14
Q

Aricept

A

Donepezil

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15
Q

Donepezil MOA

A

Reversibly and non-competitively inhibits centrally active acetylcholinesterase, the enzyme that hydrolyzes acetylcholine. Results in increased concentrations of acetylcholine available for synaptic transmission.

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16
Q

Donepezil class

A

Acetylcholinesterase inhibitor

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17
Q

Doxil

A

Doxorubicin

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18
Q

Adriamycin

A

Doxorubicin

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19
Q

Doxorubicin MOA

A

Inhibits DNA and RNA synthesis by intercalating between DNA base pairs, by inhibition of topoisomerase II, and by steric obstruction. Also chelates iron, and the complex can bind DNA and cell membranes and produce free radicals that immediately cleave DNA and cell membranes.

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20
Q

Doxorubicin class

A

Anthracycline; topoisomerase II inhibitor (antineoplastic)

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21
Q

Vibramycin

A

Doxycycline

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22
Q

Doxycycline MOA

A

Inhibits protein synthesis by binding to the 30S, and possibly the 50S ribosomal subunits of bacteria

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23
Q

Doxycycline class

A

tetracycline

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24
Q

Cymbalta

A

Duloxetine

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25
Duloxetine MOA
Inhibitor of neuronal serotonin and norepinephrine reuptake and a weak inhibitor of dopamine reuptake.
26
Duloxetine class
Serotonin/norepinephrine reuptake inhibitor
27
Relpax
Eletriptan
28
Eletriptan MOA
Selective agonist for serotonin (5-HT1B, 5-HT1D, and 5-HT1F receptors) in cranial arteries; causes vasoconstriction and reduces inflammation associated with neuronal transmission, correlating with relief of migraine.
29
Eletriptan class
Serotonin 5-HT1B, 1D receptor agonist (antimigraine agent)
30
Baraclude
Entecavir
31
Entecavir MOA
Intracellularly phosphorylated and competes with natural substrates to effectively inhibit hepatitis B viral polymerase; enzyme inhibition blocks reverse transcriptase activity, thereby reducing viral DNA synthesis.
32
Entecavir class
Reverse transcriptase inhibitor, nucleoside (anti-HBV)
33
Epogen
Epoetin
34
Procrit
Epoetin
35
Epoetin MOA
Induces erythropoiesis by stimulating division and differentiation of committed erythroid progenitor cells; induces release of reticulocytes from bone marrow into the bloodstream, where they mature into erythrocytes.
36
Epoetin class
Erythropoiesis-stimulating agent (ESA); colony stimulating factor
37
Xerava
Eravacycline
38
Eravacycline MOA
Binds to 30S ribosomal subunit and prevents incorporation of amino acid residues into elongating peptide chains, thereby inhibiting bacterial protein synthesis
39
Eravacycline class
Tetracycline derivative
40
Erythrocyin
Erythromycin
41
Erythromycin MOA
Binds to 50S ribosomal subunit resulting in blockage of transpeptidation, thereby inhibiting protein synthesis
42
Erythromycin class
Macrolide
43
Lexapro
Escitalopram
44
Escitalopram MOA
Inhibits the reuptake of serotonin with little to no effect on norepinephrine or dopamine reuptake.
45
Escitalopram class
SSRI
46
Nexium
Esomeprazole
47
Esomeprazole MOA
Suppresses gastric acid secretion by inhibition of the H+/K+-ATPase in the gastric parietal cell
48
Esomeprazole class
proton pump inhibitor
49
Enbrel
Etanercept
50
Etanercept MOA
Recombinant protein composed of TNF receptor linked to the Fc portion of human IgG1. Binds to TNF and blocks its interaction with cell surface receptors.
51
Etanercept class
Biologic DMARD (anti-TNF)
52
NuvaRing
Ethinyl Estradiol and Etonogestrel ring
53
NuvaRing MOA
Combination hormonal contraceptives that inhibit ovulation via negative feedback on the hypothalamus, which alters the normal pattern of gonadotropin secretion of a follicle-stimulating hormone (FSH) and luteinizing hormone by the anterior pituitary....
54
VP16
Etoposide
55
Etoposide MOA
Topoisomerase II inhibitor and appears to cause DNA strand breaks
56
Etoposide class
Podophyllotoxin derivative, topoisomerase II inhibitor
57
Famotidine MOA
Competitive inhibition of histamine at H2 receptors of the gastric parietal cells, which inhibits gastric acid secretion
58
Famotidine class
Histamine H2 blocker
59
Uloric
Febuxostat
60
Febuxostat MOA
Selectively inhibits xanthine oxidase, therefore inhibiting the conversion of hypoxanthine to xanthine and uric acid.
61
Febuxostat class
xanthine oxidase inhibitor
62
Sublimaze
Fentanyl
63
Fentanyl MOA
Binds with stereospecific receptors at many sites within the CNS, increases pain threshold, alters pain reception, and inhibits ascending pain pathways
64
Fentanyl class
opioid analgesic
65
Duragesic
Fentanyl transdermal
66
Dificid
Fidaxomycin
67
Fidaxomycin MOA
Inhibits RNA polymerase sigma subunit resulting in inhibition of protein synthesis and cell death in susceptible organisms including C. diff
68
Fidaxomycin class
Macrolide antibiotic
69
Diflucan
Fluconazole
70
Fluconazole MOA
Interferes with fungal cytochrome P450 activity, decreasing ergosterol synthesis, and inhibiting cell membrane formation
71
Fluconazole class
azole antifungal
72
Fludara
Fludarabine
73
Fludarabine MOA
Fludarabine is an adenine analogue that interferes with DNA polymerase, causing chain termination and incorporates into RNA, resulting in inhibition of transcription.
74
Fludarabine class
Antimetabolite (purine analog) antineoplastic
75
Adrucil
Fluorouracil (5-FU)
76
Fluorouracil MOA
Active metabolite F-dUMP inhibits thymidylate synthase preventing the synthesis of thymidine needed for DNA synthesis The triphosphate metabolite is incorporated into RNA as a false base and interferes with its function
77
Fluorouracil class
Antimetabolite (pyrimidine analog)

Top 300 Drugs (9 decks)

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