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Top 300 Drugs > 6/18/2023 > Flashcards

6/18/2023 Flashcards

(100 cards)

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1
Q

Quetiapine MOA

A

Mixed 5-HT2A and D2 antagonism, results in:
Reduced DA activity in the mesolimbic pathway and reduced positive symptoms
Increased DA release from 5-HT2A antagonism in the mesocortical pathway and reduced negative symptoms
Increased DA release from 5-HT2A antagonism in the nigrostriatal pathway and less risk of EPS
Increased DA release from 5-HT2A antagonism in the tuberoinfundibular pathway and less risk for hyperprolactinemia

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2
Q

Quetiapine class

A

Second generation antipsychotic

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3
Q

AcipHex

A

Rabeprazole

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4
Q

Rabeprazole class

A

PPI

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5
Q

Elitek

A

Rasburicase

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6
Q

Rasburicase MOA

A

Rasburicase is a recombinant urate-oxidase enzyme, which converts uric acid to allantoin (a soluble metabolite of uric acid).

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7
Q

Rasburicase class

A

recombinant urate oxidase enzyme

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8
Q

Veklury

A

Remdesivir

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9
Q

Remdesivir MOA

A

Inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), which is essential for viral replication. Remdesivir gets phosphorylated and acts as a nucleotide to get incorporated into RNA, resulting in chain termination during RNA replication.

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10
Q

Rifadin

A

Rifampin

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11
Q

Rifampin MOA

A

Inhibits bacterial RNA synthesis by binding to the beta subunit of DNA-dependent RNA polymerase, blocking RNA transcription

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12
Q

Xifaxan

A

Rifaximin

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13
Q

Rifaximin MOA

A

Inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase

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14
Q

Risperidone MOA

A

Mixed 5-HT2A and D2 antagonism, results in:
Reduced DA activity in the mesolimbic pathway and reduced positive symptoms
Increased DA release from 5-HT2A antagonism in the mesocortical pathway and reduced negative symptoms
Increased DA release from 5-HT2A antagonism in the nigrostriatal pathway and less risk of EPS
Increased DA release from 5-HT2A antagonism in the tuberoinfundibular pathway and less risk for hyperprolactinemia

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15
Q

Risperidone class

A

Second generation antipsychotic

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16
Q

Rituximab MOA

A

Monoclonal antibody targeted against CD20 antigen on the surface of B cells. Rituximab binds to CD20 and initiates complement-dependent cytotoxicity.

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17
Q

Rituximab class

A

monoclonal antibody, anti-CD20; antirheumatic; antineoplastic

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18
Q

Maxalt

A

Rizatriptan

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19
Q

Rizatriptan MOA

A

Selective serotonin agonist at 5-HT1B and 5-HT1D receptors in cranial arteries. Causes vasoconstriction and reduces inflammation associated with migraine.

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20
Q

Rizatriptan class

A

serotonin 5-HT1B ,1D receptor agonist

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21
Q

Nplate

A

Romiplostim

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22
Q

Romiplostim MOA

A

Thrombepoietin (TPO) peptide mimetic that increases platelet counts in ITP by binding to and activating the human TPO receptor

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23
Q

Romiplostim class

A

Colony stimulating factor; thrombopoietic agent

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24
Q

Ropinirole MOA

A

Dopamine agonist; higher affinity for D3 than D2 and D4.

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25
Ropinirole class
anti-Parkinson agent; dopamine agonist
26
Senna MOA
Induces defecation by stimulating peristaltic activity on the intestine by direct action on the intestinal mucosa or nerve plexus, therefore increasing motility
27
Sovaldi
Sofosbuvir
28
Sofosbuvir MOA
Direct-acting antiviral agent against the hepatitis C virus; Inhibits HCV NS5B RNA-dependent RNA polymerase, essential for viral replication, and acts as a chain terminator.
29
Sofosbuvir class
Anti-HCV polymerase inhibitor; NS5B RNA polymerase inhibitor
30
St. John's Wort
Hypericum Perforatum
31
Sucralfate MOA
Forms a complex by binding with positively charged proteins in exudates, forming a viscous paste-like, adhesive substance. This selectively forms a protective coating that acts locally to protect the gastric lining against peptic acid, pepsin, and bile salt.
32
Sucralfate class
Miscellaneous GI agent
33
Imitrex
Sumatriptan
34
Sumatriptan MOA
Selective agonist for serotonin (5-HT1B and 5-HT1D) receptors on intracranial blood vessels and sensory nerves of the trigeminal system; causes vasoconstriction and reduces inflammation associated with migraine.
35
Sumatriptan class
serotonin 5-HT1B and 5-HT1D agonist
36
Prograf
Tacrolimus
37
Tacrolimus MOA
Binds to FKPB-12 (intracytosolic protein) resulting in decreased IL-2 production and therefore decreased T-cell production
38
Tacrolimus class
calcineurin inhibitor
39
Envarsus
Tacrolimus
40
Astagraf
Tacrolimus
41
Tamoxifen MOA
Competitively binds to estrogen receptors on tumors and other tissue targets, producing a nuclear complex that decreases DNA synthesis and inhibits estrogen effects; non-steroidal agent with potent antiestrogenic properties which compete with estrogen for binding sites in breast and other tissues.
42
Tamoxifen class
Selective estrogen receptor modulator (SERM)
43
Soltamox
Tamoxifen
44
Sivextro
Tedizolid
45
Tedizolid MOA
Binds to the 50S ribosomal subunit of susceptible bacteria to prevent the formation of a functional 70S complex, thereby inhibiting bacterial translation and protein synthesis
46
Tedizolid class
oxazolidinone
47
Micardis
Telmisartan
48
Telmisartan MOA
Angiotensin II receptor antagonist; prevents angiotensin II from binding to the receptor, thereby blocking the vasoconstriction and aldosterone secreting effects of angiotensin II.
49
Telmisartan class
Angiotensin II receptor blocker
50
Tygacil
Tigecycline
51
Tigecycline MOA
Binds to the 30S ribosomal subunit of susceptible bacteria, thereby inhibiting protein synthesis.
52
Tigecycline class
Glycylcycline
53
Timolol MOA
Blocks both beta1 and beta2 adrenergic receptors; reduces blood pressure by blocking adrenergic receptors and decreasing sympathetic outflow, produces a negative chronotropic and inotropic activity. For glaucoma, decreases production of aqueous humor.
54
Timolol class
non-selective beta blocker
55
Zanaflex
Tizanidine
56
Tizanidine MOA
Alpha-2 adrenergic agonist which decreases spasticity by increasing presynaptic inhibition; effects are greatest on polysynaptic pathways; overall effect is to reduce facilitation of spinal motor neurons.
57
Tizanidine class
Alpha-2 adrenergic agonist
58
Topiramate MOA
Combination of mechanisms. Blocks voltage-gated sodium channels, enhances GABA activity, agonizes AMPA/kainate glutamate receptors, and weakly inhibits carbonic anhydrase.
59
Hycamtin
Topotecan
60
Topotecan MOA
Topoisomerase inhibitor; inhibits enzymes that cleave DNA strands and form intermediates with the strands during replication, producing a gap through which DNA strands can pass and then reseal the strand breaks.
61
Topotecan class
topoisomerase inhibitor; camptothecins
62
Ultram
Tramadol
63
Tramadol MOA
Binds to mu opiate receptors in the CNS causing inhibition of ascending pain pathways, altering perception of and response to pain; also inhibits the reuptake of norepinephrine and serotonin, which are involved in the descending inhibitory pain pathway responsible for pain relief.
64
Herceptin
trastuzumab
65
Trastuzumab MOA
Monoclonal antibody that targets EGFR/HER2, mediating antibody-dependent cellular cytotoxicity by inhibiting proliferation of cells which overexpress HER2.
66
Trastuzumab class
Anti-HER2 monoclonal antibody
67
Travatan Z
Travoprost
68
Travoprost MOA
Prostanoid receptor agonist which lowers intraocular pressure by increasing outflow
69
Herzuma
Trastuzumab
70
Kantinji
Trastuzumab
71
Ogivri
Trastuzumab
72
Travoprost class
Prostaglandin
73
Desyrel
Trazodone
74
Trazodone MOA
Antagonist of the 5-HT2A receptor which allows more 5-HT to interact with 5-HT1A at postsynaptic sites; weak to moderate presynaptic alpha adrenergic inhibitor and modest antagonist of the H1 receptor
75
Trazodone class
Serotonin antagonist
76
Halcion
Triazolam
77
Trimethoprim/sulfamethoxazole MOA
Sulfamethoxazole interferes with bacterial folic acid synthesis and growth via inhibition of dihydrofolic acid formation from para-aminobenzoic acid. Trimethoprim inhibits dihydrofolic acid reduction to tetrahydrofolate resulting in sequential inhibition of enzymes of the folic acid pathway.
78
Sulfamethoxazole/trimethoprim class
Sulfonamide derivative, antibiotic
79
Stelara
Ustekinumab
80
Ustekinumab MOA
Monoclonal antibody that binds to proinflammatory cytokines, IL-12 and IL-23. Reduces NK cell activation and CD4 T cell differentiation and activation.
81
Ustekinumab class
Anti-IL-12 and IL-23 monoclonal antibody; antipsoriatic agent
82
Valacyclovir MOA
Prodrug of acyclovir. Acyclovir gets phosphorylated and incorporated into DNA. Also competes for natural substrate for viral DNA polymerase, thereby preventing DNA synthesis.
83
Vancocin
Vancomycin
84
Vancomycin MOA
Inhibits bacterial cell wall synthesis by blocking glycopeptide polymerization through binding tightly to D-alanyl-D-alanine portion of peptidoglycan.
85
Vancomycin class
Glycopeptide
86
Venlafaxine MOA
Inhibits neuronal serotonin and norepinephrine reuptake. Also weakly inhibits dopamine reuptake.
87
Venlafaxine class
Serotonin/norepinephrine reuptake inhibitor
88
Velban
Vinblastine
89
Vinblastine MOA
Binds to tubulin and inhibits microtubule formation, thereby disrupting the formation of the mitotic spindle and stopping the cell cycle at metaphase.
90
Vinblastine class
Vinca alkaloid; antimicrotubular
91
Vincasar
Vincristine
92
Vincristine MOA
Binds to tubulin and inhibits microtubule formation, thereby disrupting the formation of the mitotic spindle and arresting the cell at metaphase.
93
Navelbine
Vinorelbine
94
Vinorelbine MOA
Semisynthetic vinca alkaloid that binds to tubulin and inhibits microtubule formation, thereby disrupting the formation the mitotic spindle and disrupting the cell cycle at metaphase.
95
Vfend
Voriconazole
96
Voriconazole MOA
Inhibits fungal CYP450, decreasing ergosterol synthesis and inhibiting fungal cell membrane function
97
Geodon
Ziprasidone
98
Ziprasidone MOA
Mixed 5-HT2A and D2 antagonism, results in: Reduced DA activity in the mesolimbic pathway and reduced positive symptoms Increased DA release from 5-HT2A antagonism in the mesocortical pathway and reduced negative symptoms Increased DA release from 5-HT2A antagonism in the nigrostriatal pathway and less risk of EPS Increased DA release from 5-HT2A antagonism in the tuberoinfundibular pathway and less risk for hyperprolactinemia
99
Ziprasidone class
Second generation antipsychotic
100
Zolpidem MOA
Enhances the activity of GABA via selective agonism at the benzodiazepine receptor. Results in increased chloride conductance, neuronal hyperpolarization, inhibition of the action potential, and decrease in neuronal excitability leading to sedative and hypnotic effects.

Top 300 Drugs (9 decks)

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